Characterization of phenolic extracts from Brava extra virgin olive oils and their cytotoxic effects on MCF-7 breast cancer cells

被引：34

作者：

Reboredo-Rodriguez, Patricia ^{[1
,2
]}

Gonzalez-Barreiro, Carmen ^{[2
]}

Cancho-Grande, Beatriz ^{[2
]}

Forbes-Hernandez, Tamara Y. ^{[1
]}

Gasparrini, Massimiliano ^{[1
]}

Afrin, Sadia ^{[1
]}

Cianciosi, Danila ^{[1
]}

Carrasco-Pancorbo, Alegria ^{[3
]}

Simal-Gandara, Jesus ^{[2
]}

Giampieri, Francesca ^{[1
]}

Battino, Maurizio ^{[1
]}

机构：

[1] Univ Politecn Marche, Dipartimento Sci Clin Specialist & Odontostomatol, Fac Med, Sez Biochim, Ancona, Italy

[2] Univ Vigo, Nutr & Bromatol Grp, Dept Analyt & Food Chem, Fac Sci, Ourense Campus, E-32004 Orense, Spain

[3] Univ Granada, Dept Analyt Chem, Fac Sci, Ave Fuentenueva S-N, E-18071 Granada, Spain

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2018年 / 119卷

关键词：

Olive oil; Phenolic compounds; Cytotoxicity; Intracellular reactive oxygen species; Apoptosis; Breast cancer; MONOUNSATURATED FATTY-ACIDS; IN-VITRO; MITOCHONDRIAL-FUNCTION; ANTIOXIDANT PROPERTIES; STRAWBERRY EXTRACT; MEDITERRANEAN DIET; OXIDATIVE STRESS; APOPTOSIS; OLEUROPEIN; ROS;

D O I：

10.1016/j.fct.2018.05.026

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The aim of the present work was to evaluate the phenolic profile of the 'Brava' extra virgin olive oil and assess its potential as a "natural adjuvant" in combination with chemotherapy treatment. The total phenol content of the phenolic extracts was 764 mg gallic acid equivalents/kg and the total antioxidant capacity was 2309, 1881 and 2088 mu M trolox equivalents/kg determined by Diphenyl-l-picrylhydrazyl free radical method, Ferric Reducing Antioxidant Power and Trolox Equivalent Antioxidant Capacity assay, respectively. Secoiridoids comprised 83% of the total phenolic compounds. The main secoiridoid from oleuropein was the main isomer of oleuropein aglycone (74 mg/kg). The main secoiridoid from ligstroside was the main isomer of ligstroside aglycone (214 mg/kg). These phenolic extracts showed a significant decrease in cell viability on MCF-7 breast cancer cells in a dose and time dependent manner. 48 h-treatments with different concentrations of the extracts induced intracellular ROS generation and cell death.

引用

页码：73 / 85

页数：13

共 66 条

[1] Antiproliferative effect of oleuropein in prostate cell lines [J].

Acquaviva, Rosaria ;

Di Giacomo, Claudia ;

Sorrenti, Valeria ;

Galvano, Fabio ;

Santangelo, Rosa ;

Cardile, Venera ;

Gangia, Silvia ;

D'Orazio, Nicolantonio ;

Abraham, Nader G. ;

Vanella, Luca .

INTERNATIONAL JOURNAL OF ONCOLOGY, 2012, 41 (01) :31-38

[2] Modulation of bitterness and pungency in virgin olive oil from unripe "Picual" fruits [J].

Aguilera, Maria P. ;

Jimenez, Antonio ;

Sanchez-Villasclaras, Sebastian ;

Uceda, Marino ;

Beltran, Gabriel .

EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY, 2015, 117 (09) :1463-1472

[3] Olive Phenolics as c-Met Inhibitors: (-)-Oleocanthal Attenuates Cell Proliferation, Invasiveness, and Tumor Growth in Breast Cancer Models [J].

Akl, Mohamed R. ;

Ayoub, Nehad M. ;

Mohyeldin, Mohamed M. ;

Busnena, Belnaser A. ;

Foudah, Ahmed I. ;

Liu, Yong-Yu ;

El Sayed, Khalid A. .

PLOS ONE, 2014, 9 (05)

[4] Antioxidant, Antiproliferative, and Pro-apoptotic Capacities of Pentacyclic Triterpenes Found in the Skin of Olives on MCF-7 Human Breast Cancer Cells and Their Effects on DNA Damage [J].

Allouche, Yosra ;

Warleta, Fernando ;

Campos, Maria ;

Sanchez-Quesada, Cristina ;

Uceda, Marino ;

Beltran, Gabriel ;

Juan Gaforio, Jose .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2011, 59 (01) :121-130

[5] Radical-scavenging Activity, Protective Effect Against Lipid Peroxidation and Mineral Contents of Monofloral Cuban Honeys [J].

Alvarez-Suarez, Jose M. ;

Giampieri, Francesca ;

Damiani, Elisabetta ;

Astolfi, Paola ;

Fattorini, Daniele ;

Regoli, Francesco ;

Quiles, Jose L. ;

Battino, Maurizio .

PLANT FOODS FOR HUMAN NUTRITION, 2012, 67 (01) :31-38

[6]

[Anonymous], MAHIDOL U J PHARM SC

[7] The olive oil phenolic (-)-oleocanthal modulates estrogen receptor expression in luminal breast cancer in vitro and in vivo and synergizes with tamoxifen treatment [J].

Ayoub, Nehad M. ;

Siddique, Abu Bakar ;

Ebrahim, Hassan Y. ;

Mohyeldin, Mohamed M. ;

El Sayed, Khalid A. .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2017, 810 :100-111

[8] Mediterranean diet pyramid today. Science and cultural updates [J].

Bach-Faig, Anna ;

Berry, Elliot M. ;

Lairon, Denis ;

Reguant, Joan ;

Trichopoulou, Antonia ;

Dernini, Sandro ;

Xavier Medina, F. ;

Battino, Maurizio ;

Belahsen, Rekia ;

Miranda, Gemma ;

Serra-Majem, Lluis .

PUBLIC HEALTH NUTRITION, 2011, 14 (12A) :2274-2284

[9] Evaluating the potential of phenolic profiles as discriminant features among extra virgin olive oils from Moroccan controlled designations of origin [J].

Bajoub, Aadil ;

Ajal, El Amine ;

Fernandez-Gutierrez, Alberto ;

Carrasco-Pancorbo, Alegria .

FOOD RESEARCH INTERNATIONAL, 2016, 84 :41-51

[10] Triterpenoids as potential agents for the chemoprevention and therapy of breast cancer [J].

Bishayee, Anupam ;

Ahmed, Shamima ;

Brankov, Nikoleta ;

Perloff, Marjorie .

FRONTIERS IN BIOSCIENCE-LANDMARK, 2011, 16 :980-996

← 1 2 3 4 5 6 7 →