Heat Shock Proteins and Cytochrome P450 1a1 Expression as Biomarkers of Exposure to Bisphenol A in Catla catla

被引：2

作者：

Faheem, Mehwish ^{[1
]}

Rafeeq, Maleeha ^{[1
]}

Majeed, Aisha ^{[1
]}

Khaliq, Saba ^{[2
]}

机构：

[1] Govt Coll Univ, Dept Zool, Lahore, Pakistan

[2] Univ Hlth Sci, Dept Physiol & Cell Biol, Lahore, Pakistan

来源：

PAKISTAN JOURNAL OF ZOOLOGY | 2020年 / 52卷 / 01期

关键词：

Bisphenol-A (BPA); Biomarkers; Heat shock proteins; cyp1a1; Catla catla; GENE-EXPRESSION; STRESS-RESPONSE; FISH; HEAT-SHOCK-PROTEIN-70; ACTIVATION; ENZYMES; INDUCE; CYP1A1; HSP70; LIVER;

D O I：

10.17582/journal.pjz/2020.52.1.sc9

中图分类号：

Q95 [动物学];

学科分类号：

071002 ;

摘要：

Biomarkers are extensively used to evaluate the early adverse effects of a toxicant exposure in an organism. Freshwater is exposed to many anthropogenic compounds that adversely affect aquatic life especially, fish population. Effect of acute exposure of low concentrations of BPA (10, 100, 1000 mu g/l) on liver cyp1a1 and heat shock proteins mRNA level was evaluated using real time qPCR. Results revealed that exposure to bisphenol A caused decrease expression of cyp1a1 in a concentration dependent manner. Exposure to graded concentrations of bisphenol-A resulted in significant increase in mRNA expression of heat shock proteins (hsp70 and hsp90). In the light of present results, expression of cyp1a1 or heat shock proteins may be used as biomarkers to assess the presence of BPA in the environment.

引用

页码：401 / 404

页数：4

共 36 条

[1] Activation of the hsp70 promoter by environmental inorganic and organic chemicals:: relationships with cytotoxicity and lipophilicity [J].