APOE ε4 Genotype and the Risk for Subjective Cognitive Impairment in Elderly Persons

被引：11

作者：

Krell-Roesch, Janina ^{[1
,2
,3
]}

Woodruff, Bryan K. ^{[1
]}

Acosta, Jazmin I. ^{[1
]}

Locke, Dona E. ^{[1
]}

Hentz, Joseph G. ^{[1
]}

Stonnington, Cynthia M. ^{[1
]}

Stokin, Gorazd B. ^{[2
,3
]}

Nagle, Chelsea ^{[1
]}

Michel, Bernard F. ^{[4
]}

Sambuchi, Nathalie ^{[4
]}

Caselli, Richard J. ^{[1
]}

Geda, Yonas E. ^{[1
,2
,3
]}

机构：

[1] Mayo Clin, Scottsdale, AZ USA

[2] Int Clin Res Ctr, Brno, Czech Republic

[3] St Annes Univ Hosp, Brno, Czech Republic

[4] Hop St Marguerite, Marseille, France

来源：

JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES | 2015年 / 27卷 / 04期

关键词：

MEMORY FUNCTIONING QUESTIONNAIRE; MINI-MENTAL-STATE; APOLIPOPROTEIN-E; ALZHEIMERS-DISEASE; OLDER-ADULTS; COMPLAINTS; ALLELE; ASSOCIATION; DECLINE; SELF;

D O I：

10.1176/appi.neuropsych.14100268

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors compared the risk for subjective cognitive impairment (SCI) between carriers of the apolipoprotein E epsilon 4 (APOE epsilon 4) allele (cases) and APOE epsilon 4 noncarriers (controls). SCI was assessed by a validated self-reported questionnaire. The authors used multivariable logistic regression analyses to compute odds ratios and 95% confidence intervals adjusted for age, sex, education, and marital status. Data were available on 114 participants (83 women; 47 APOE epsilon 4 carriers; mean age, 69 years). The risk for SCI was significantly higher among cases than controls, particularly for those 70 years of age and older. These findings should be considered preliminary until confirmed by a prospective cohort study.

引用

页码：322 / 325

页数：4

共 38 条

[1] Specific Subjective Memory Complaints in Older Persons May Indicate Poor Cognitive Function [J].

Amariglio, Rebecca England ;

Townsend, Mary K. ;

Grodstein, Francine ;

Sperling, Reisa A. ;

Rentz, Dorene M. .

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2011, 59 (09) :1612-1617

[2] High apolipoprotein E epsilon 4 allele frequency in age-related memory decline [J].

Blesa, R ;

Adroer, R ;

Santacruz, P ;

Ascaso, C ;

Tolosa, E ;

Oliva, R .

ANNALS OF NEUROLOGY, 1996, 39 (04) :548-551

[3] The APOE ε4 Allele Is Associated with Incident Mild Cognitive Impairment among Community-Dwelling Older Persons [J].

Boyle, Patricia A. ;

Buchman, Aron S. ;

Wilson, Robert S. ;

Kelly, Jeremiah F. ;

Bennett, David A. .

NEUROEPIDEMIOLOGY, 2010, 34 (01) :43-49

[4] Subjective cognitive decline: Self and informant comparisons [J].

Caselli, Richard J. ;

Chen, Kewei ;

Locke, Dona E. C. ;

Lee, Wendy ;

Roontiva, Auttawut ;

Bandy, Dan ;

Fleisher, Adam S. ;

Reiman, Eric M. .

ALZHEIMERS & DEMENTIA, 2014, 10 (01) :93-98

[5] Longitudinal Modeling of Age-Related Memory Decline and the APOE ε4 Effect [J].

Caselli, Richard J. ;

Dueck, Amylou C. ;

Osborne, David ;

Sabbagh, Marwan N. ;

Connor, Donald J. ;

Ahern, Geoffrey L. ;

Baxter, Leslie C. ;

Rapcsak, Steven Z. ;

Shi, Jiong ;

Woodruff, Bryan K. ;

Locke, Dona E. C. ;

Snyder, Charlene Hoffman ;

Alexander, Gene E. ;

Rademakers, Rosa ;

Reiman, Eric M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (03) :255-263

[6] GENE DOSE OF APOLIPOPROTEIN-E TYPE-4 ALLELE AND THE RISK OF ALZHEIMERS-DISEASE IN LATE-ONSET FAMILIES [J].

CORDER, EH ;

SAUNDERS, AM ;

STRITTMATTER, WJ ;

SCHMECHEL, DE ;

GASKELL, PC ;

SMALL, GW ;

ROSES, AD ;

HAINES, JL ;

PERICAKVANCE, MA .

SCIENCE, 1993, 261 (5123) :921-923

[7] POPULATION-BASED NORMS FOR THE MINI-MENTAL-STATE-EXAMINATION BY AGE AND EDUCATIONAL-LEVEL [J].

CRUM, RM ;

ANTHONY, JC ;

BASSETT, SS ;

FOLSTEIN, MF .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1993, 269 (18) :2386-2391

[8] Memory complaints and APOE-ε4 accelerate cognitive decline in cognitively normal elderly [J].

Dik, MG ;

Jonker, C ;

Comijs, HC ;

Bouter, LM ;

Twisk, JWR ;

van Kamp, GJ ;

Deeg, DJH .

NEUROLOGY, 2001, 57 (12) :2217-2222

[9] Revising the definition of Alzheimer's disease: a new lexicon [J].

Dubois, Bruno ;

Feldman, Howard H. ;

Jacova, Claudia ;

Cummings, Jeffrey L. ;

DeKosky, Steven T. ;

Barberger-Gateau, Pascale ;

Delacourte, Andre ;

Frisoni, Giovanni ;

Fox, Nick C. ;

Galasko, Douglas ;

Gauthier, Serge ;

Hampel, Harald ;

Jicha, Gregory A. ;

Meguro, Kenichi ;

O'Brien, John ;

Pasquier, Florence ;

Robert, Philippe ;

Rossor, Martin ;

Salloway, Steven ;

Sarazin, Marie ;

de Souza, Leonardo C. ;

Stern, Yaakov ;

Visser, Pieter J. ;

Scheltens, Philip .

LANCET NEUROLOGY, 2010, 9 (11) :1118-1127

[10] MINI-MENTAL STATE - PRACTICAL METHOD FOR GRADING COGNITIVE STATE OF PATIENTS FOR CLINICIAN [J].

FOLSTEIN, MF ;

FOLSTEIN, SE ;

MCHUGH, PR .

JOURNAL OF PSYCHIATRIC RESEARCH, 1975, 12 (03) :189-198

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