Rhodium-Catalyzed Merging of 2-Arylquinazolinone and 2,2-Difluorovinyl Tosylate: Diverse Synthesis of Monofluoroolefin Quinazolinone Derivatives

被引：14

作者：

Wang, Ning ^{[1
]}

Yang, Qin ^{[1
]}

Deng, Zhihong ^{[1
]}

Mao, Xuechun ^{[1
]}

Peng, Yiyuan ^{[1
]}

机构：

[1] Jiangxi Normal Univ, Key Lab Funct Small Organ Mol, Jiangxi Prov Key Lab Green Chem, Minist Educ, Nanchang 330022, Jiangxi, Peoples R China

来源：

ACS OMEGA | 2020年 / 5卷 / 24期

基金：

中国国家自然科学基金;

关键词：

FLUORINATED ALCOHOLS; H FLUOROALKENYLATION; INHIBITORS; FUNCTIONALIZATION; PHARMACEUTICALS; HETEROARENES; ALKALOIDS; CHEMISTRY; QUINOLINE; MIMICS;

D O I：

10.1021/acsomega.0c01344

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient method for the synthesis of 2-(o-monofluoroalkenylaryl)quinazolinone derivatives was developed. In this context, the quinazolinone ring served as the inherent directing group, 2,2-difluorovinyl tosylate was used as the monofluoroolefin synthon, and Rh(III)-catalyzed C-H bond difluorovinylation of 2-arylquinazolinons was performed to give the corresponding monofluoroalkene-containing quinazolinons in yields of 65-92%. The method is characterized by broad synthetic utility, mild conditions, and high efficiency.

引用

页码：14635 / 14644

页数：10

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