Savior or not: ADAM17 inhibitors overcome radiotherapy-resistance in non-small cell lung cancer

被引：9
作者：
Ieguchi, Katsuaki [1 ]
Maru, Yoshiro [1 ]
机构：
[1] Tokyo Womens Med Univ, Dept Pharmacol, Shinjuku Ku, 8-1 Kawada Cho, Tokyo 1628666, Japan
来源：
JOURNAL OF THORACIC DISEASE | 2016年 / 8卷 / 08期
关键词：
RHEUMATOID-ARTHRITIS; CONVERTING ENZYME; CRYSTAL-STRUCTURE; CATALYTIC DOMAIN; TUMOR; INFLAMMATION; DISINTEGRIN; PROGRESSION; TARGET; EPH;
D O I：
10.21037/jtd.2016.07.56
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
[No abstract available]
引用
收藏
页码：E813 / E815
页数：3
相关论文
共 20 条
  • [1] The disintegrin and metalloproteinase ADAM12 contributes to TGF-β signaling through interaction with the type II receptor
    Atfi, Azeddine
    Dumont, Emmanuelle
    Colland, Frederic
    Bonnier, Dominique
    L'Helgoualc'h, Annie
    Prunier, Celine
    Ferrand, Nathalie
    Clement, Bruno
    Wewer, Ulla M.
    Theret, Nathalie
    [J]. JOURNAL OF CELL BIOLOGY, 2007, 178 (02) : 201 - 208
  • [2] Standard-dose versus high-dose conformal radiotherapy with concurrent and consolidation carboplatin plus paclitaxel with or without cetuximab for patients with stage IIIA or IIIB non-small-cell lung cancer (RTOG 0617): a randomised, two-by-two factorial phase 3 study
    Bradley, Jeffrey D.
    Paulus, Rebecca
    Komaki, Ritsuko
    Masters, Gregory
    Blumenschein, George
    Schild, Steven
    Bogart, Jeffrey
    Hu, Chen
    Forster, Kenneth
    Magliocco, Anthony
    Kavadi, Vivek
    Garces, Yolanda I.
    Narayan, Samir
    Iyengar, Puneeth
    Robinson, Cliff
    Wynn, Raymond B.
    Koprowski, Christopher
    Meng, Joanne
    Beitler, Jonathan
    Gaur, Rakesh
    Curran, Walter, Jr.
    Choy, Hak
    [J]. LANCET ONCOLOGY, 2015, 16 (02) : 187 - 199
  • [3] Targeting ADAM-17 with an inhibitory monoclonal antibody has antitumour effects in triple-negative breast cancer cells
    Caiazza, F.
    McGowan, P. M.
    Mullooly, M.
    Murray, A.
    Synnott, N.
    O'Donovan, N.
    Flanagan, L.
    Tape, C. J.
    Murphy, G.
    Crown, J.
    Duffy, M. J.
    [J]. BRITISH JOURNAL OF CANCER, 2015, 112 (12) : 1895 - 1903
  • [4] Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice
    Chalaris, Athena
    Adam, Nina
    Sina, Christian
    Rosenstiel, Philip
    Lehmann-Koch, Judith
    Schirmacher, Peter
    Hartmann, Dieter
    Cichy, Joanna
    Gavrilova, Olga
    Schreiber, Stefan
    Jostock, Thomas
    Matthews, Vance
    Haesler, Robert
    Becker, Christoph
    Neurath, Markus F.
    Reiss, Karina
    Saftig, Paul
    Scheller, Juergen
    Rose-John, Stefan
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2010, 207 (08) : 1617 - 1624
  • [5] ADAM12 Produced by Tumor Cells Rather than Stromal Cells Accelerates Breast Tumor Progression
    Frohlich, Camilla
    Nehammer, Camilla
    Albrechtsen, Reidar
    Kronqvist, Pauliina
    Kveiborg, Marie
    Sehara-Fujisawa, Atsuko
    Mercurio, Arthur M.
    Wewer, Ulla M.
    [J]. MOLECULAR CANCER RESEARCH, 2011, 9 (11) : 1449 - 1461
  • [6] The role of EGFR and ErbB family related proteins in the oligodendrocyte specification in germinal niches of the adult mammalian brain
    Galvez-Contreras, Alma Y.
    Quinones-Hinojosa, Alfredo
    Gonzalez-Perez, Oscar
    [J]. FRONTIERS IN CELLULAR NEUROSCIENCE, 2013, 7
  • [7] EGFR point mutation confers resistance to gefitinib in a patient with non-small-cell lung cancer
    Giaccone, G
    [J]. NATURE CLINICAL PRACTICE ONCOLOGY, 2005, 2 (06): : 296 - 297
  • [8] Cutting edge:: TNF-α-cinverting enzyme (TACE/ADAM17) inactivation in mouse myeloid cells prevents lethality from endotoxin shock
    Horiuchi, Keisuke
    Kimura, Tokuhiro
    Miyamoto, Takeshi
    Takaishi, Hironari
    Okada, Yasunori
    Toyama, Yoshiaki
    Blobel, Carl P.
    [J]. JOURNAL OF IMMUNOLOGY, 2007, 179 (05) : 2686 - 2689
  • [9] Cysteine-rich domain of human ADAM 12 (meltrin α) supports tumor cell adhesion
    Iba, K
    Albrechtsen, R
    Gilpin, BJ
    Loechel, F
    Wewer, UM
    [J]. AMERICAN JOURNAL OF PATHOLOGY, 1999, 154 (05) : 1489 - 1501
  • [10] Eph as a Target in Inflammation
    Ieguchi, Katsuaki
    [J]. ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS, 2015, 15 (02) : 119 - 128
12