Effects of paeonol on the expression of NF-κB pathways in human umbilical veins endothelial cells induced by homocysteine

被引：2

作者：

Xu, Qian ^{[1
]}

Cao, Kai ^{[2
]}

Xiao, Yan-Hong ^{[2
]}

Du, Chao ^{[1
]}

Dong, Xian-Hui ^{[3
]}

Wang, Yu ^{[1
]}

Zhou, Xiao-Hui ^{[2
]}

机构：

[1] Sch Chengde Med Coll, Chengde 067000, Hebei, Peoples R China

[2] Sch Chengde Med Coll, Dept Biochem, Chengde 067000, Hebei, Peoples R China

[3] Sch Chengde Med Coll, Dept Anat, Chengde 067000, Hebei, Peoples R China

来源：

BANGLADESH JOURNAL OF PHARMACOLOGY | 2015年 / 10卷 / 03期

关键词：

ATHEROSCLEROSIS;

D O I：

10.3329/bjp.v10i3.23414

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The aim of this study was to investigate the effects of paeonol on the expression of NF-kappa B pathway induced by homocysteine. After Human umbilical vein endothelial cells exposed to homocysteine for 24 hours, paeonol (0.15-0.6 mmol/L) improved the cell viability (p<0.05). NF-kappa B p65 mRNA expression was reduced largely (p<0.05) and I kappa B-alpha protein expression increased significantly (p<0.01). The staining of NF-kappa B p65 in nucleus was not as much as those in homocysteine injured model group (p<0.01). Therefore, paeonol can inhibit I kappa B-alpha protein degradation and suppress NF-kappa B transferred into nuclear in order to inhibit the activation of NF-kappa B.

引用

页码：604 / 611

页数：8

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