Enhanced pathogenesis of an attenuated herpes simplex virus for mice lacking Stat1

被引：24

作者：

Pasieka, Tracy Jo ^{[1
]}

Lu, Betty ^{[1
]}

Leib, David A. ^{[1
,2
]}

机构：

[1] Washington Univ, Sch Med, Dept Ophthalmol & Visual Sci, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA

来源：

JOURNAL OF VIROLOGY | 2008年 / 82卷 / 12期

关键词：

D O I：

10.1128/JVI.00297-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Mice lacking the Stat1 interferon signaling gene were infected with herpes simplex virus type 1 (HSV-1) or an attenuated recombinant lacking virion host shutoff (Delta vhs). Delta vhs virus-infected Stat1(-/-) mice showed levels of replication equivalent to that of the wild-type virus-infected control mice but reduced relative to wild-type virus-infected Stat1(-/-) mice. Stat1 deficiency relieves the immunomodulatory deficiency of Delta vhs virus, but not its inherent growth defect. Also Vhs is dispensable for reactivation.

引用

页码：6052 / 6055

页数：4

共 29 条

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