Enhancing Effects of Chronic Lithium Treatment on Detour Learning in Chicks

被引：6

作者：

Zhang, Lei ^{[1
]}

Chen, Xiaoyun ^{[1
]}

Feng, Wei ^{[1
]}

Liang, Hui ^{[1
]}

Cui, Yonghua ^{[1
]}

Xu, Shiqing ^{[1
]}

Che, Yi ^{[1
]}

机构：

[1] Soochow Univ, Coll Med, Suzhou 215123, Peoples R China

来源：

BIOLOGICAL TRACE ELEMENT RESEARCH | 2012年 / 148卷 / 01期

关键词：

Lithium; Chick; Central nervous system; Detour learning; HIPPOCAMPAL NEUROGENESIS; NEUROTROPHIC FACTOR; DOMESTIC CHICKS; MEMORY; RAT; BEHAVIOR; LTP; INCREASES; COGNITION; MATTER;

D O I：

10.1007/s12011-012-9334-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lithium is the first line of therapeutic drugs used to treat both mania and depression in bipolar disorder. Although a body of research suggests that lithium acts as a cognitive enhancer, other animal studies suggest that lithium induces cognitive deficits. Comparatively, the effects of lithium on cognitive behaviour in these studies are inconsistent and contradictory. Further investigations in different species of animals and behavioural tasks are important to evaluate the possibility that lithium may act as a cognitive enhancer. In the present study, the chicks were treated intraperitoneally with lithium chloride (120 mg/kg), and the effects of chronic lithium treatment on chick cognitive behaviour were examined using a detour learning task. Additionally, the effects of chronic lithium treatment on BDNF messenger RNA (mRNA) expression were measured in RTPCR. We found that chronic lithium treatment (120 mg/kg) had no effect on spontaneous motor activity or weight gain of the chicks and that the chicks had a general healthy appearance, while chronic lithium treatment significantly promoted the response latency of detour learning and BDNF mRNA expression. These results suggest that chronic lithium treatment may improve cognitive function.

引用

页码：38 / 43

页数：6

共 42 条

[1] Chromatin acetylation, memory, and LTP are impaired in CBP+/- mice:: A model for the cognitive deficit in Rubinstein-Taybi syndrome and its amelioration [J].

Alarcón, JM ;

Malleret, G ;

Touzani, K ;

Vronskaya, S ;

Ishii, S ;

Kandel, ER ;

Barco, A .

NEURON, 2004, 42 (06) :947-959

[2] A critical role of CREB in the impairment of late-phase LTP by adult onset hypothyroidism [J].

Alzoubi, K. H. ;

Alkadhi, K. A. .

EXPERIMENTAL NEUROLOGY, 2007, 203 (01) :63-71

[3] INVOLVEMENT OF LTP IN MEMORY - ARE WE SEARCHING UNDER THE STREET LIGHT [J].

BARNES, CA .

NEURON, 1995, 15 (04) :751-754

[4] Persistence of long-term memory storage requires a late protein synthesis- and BDNF-dependent phase in the hippocampus [J].

Bekinschtein, Pedro ;

Cammarota, Martin ;

Igaz, Lionel Muller ;

Bevilaqua, Lia R. M. ;

Izquierdo, Ivan ;

Medina, Jorge H. .

NEURON, 2007, 53 (02) :261-277

[5] Relationships between midembryonic 5-HT2 agonist and/or antagonist exposure and detour learning by chickens [J].

Bollweg, G ;

Sparber, SB .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1998, 60 (01) :47-53

[6] LITHIUM TREATMENT BLOCKS LONG-TERM SYNAPTIC DEPRESSION IN THE STRIATUM [J].

CALABRESI, P ;

PISANI, A ;

MERCURI, NB ;

BERNARDI, G .

NEURON, 1993, 10 (05) :955-962

[7] EFFECTS OF LITHIUM ON APPETITIVE DISCRIMINATION IN THE RAT [J].

CAPPELIEZ, P ;

MOORE, E ;

SOULIERE, M .

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 1989, 13 (05) :725-734

[8] EFFECTS OF LITHIUM ON LATENT INHIBITION IN THE RAT [J].

CAPPELIEZ, P ;

MOORE, E .

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 1988, 12 (04) :431-443

[9] Effect of chronic lithium treatment on the turnover of α2-adrenoceptors after chemical inactivation in rats [J].

Carbonell, L ;

Cuffi, ML ;

Forn, J .

EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2004, 14 (06) :497-502

[10] Effects of exposure to 50 Hz magnetic field of 1 mT on the performance of detour learning task by chicks [J].

Che, Yi ;

Sun, Huaying ;

Cui, Yonghua ;

Zhou, Dongming ;

Ma, Yuanye .

BRAIN RESEARCH BULLETIN, 2007, 74 (1-3) :178-182

← 1 2 3 4 5 →