Towards the synthesis of spongistatin 1: Diastereoselective synthesis of the C(36)-C(45) subunit

被引：29
作者：
Micalizio, GC [1 ]
Roush, WR [1 ]
机构：
[1] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
来源：
TETRAHEDRON LETTERS | 1999年 / 40卷 / 17期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/S0040-4039(99)00464-5
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient and highly diastereoselective 12 step synthesis of the C(36)-C(45) subunit (2a) of spongistatin 1 is described. The synthesis features highly diastereoselective alpha-alkoxyallylation reactions using the gamma-alkoxy substituted allylstannanes 5 and 6, and a thermodynamically controlled intramolecular Michael addition to close the pyran, (C) 1999 Elsevier Science Ltd. All rights reserved.
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收藏
页码：3351 / 3354
页数：4
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