Deformylation of indole and azaindole-3-carboxaldehydes using anthranilamide and solid acid heterogeneous catalyst via quinazolinone intermediate

被引:11
作者
Yadav, Rammohan R. [1 ]
Battini, Narsaiah [1 ]
Mudududdla, Ramesh [1 ]
Bharate, Jaideep B. [1 ]
Muparappu, Nagaraju [1 ]
Bharate, Sandip B. [1 ]
Vishwakarma, Ram A. [1 ]
机构
[1] Indian Inst Integrat Med, CSIR, Div Med Chem, Jammu 180001, India
关键词
Azaindole; Deformylation; Heterogeneous catalyst; Indole; Indole aldehyde; Quinazolinone; DECARBONYLATION; ALKALOIDS; ALDEHYDES; EFFICIENT; RING;
D O I
10.1016/j.tetlet.2012.02.079
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The deformylation of indole and azaindole-3-carboxaldehydes was achieved in the presence of anthranilamide and a solid acid heterogeneous catalyst under reflux conditions in 25-90% yield. The reaction proceeds via quinazolinone intermediate, which undergoes acid catalyzed cleavage to form deformylated product. (c) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码:2222 / 2225
页数:4
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