Deformylation of indole and azaindole-3-carboxaldehydes using anthranilamide and solid acid heterogeneous catalyst via quinazolinone intermediate

被引：11

作者：

Yadav, Rammohan R. ^{[1
]}

Battini, Narsaiah ^{[1
]}

Mudududdla, Ramesh ^{[1
]}

Bharate, Jaideep B. ^{[1
]}

Muparappu, Nagaraju ^{[1
]}

Bharate, Sandip B. ^{[1
]}

Vishwakarma, Ram A. ^{[1
]}

机构：

[1] Indian Inst Integrat Med, CSIR, Div Med Chem, Jammu 180001, India

来源：

TETRAHEDRON LETTERS | 2012年 / 53卷 / 17期

关键词：

Azaindole; Deformylation; Heterogeneous catalyst; Indole; Indole aldehyde; Quinazolinone; DECARBONYLATION; ALKALOIDS; ALDEHYDES; EFFICIENT; RING;

D O I：

10.1016/j.tetlet.2012.02.079

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The deformylation of indole and azaindole-3-carboxaldehydes was achieved in the presence of anthranilamide and a solid acid heterogeneous catalyst under reflux conditions in 25-90% yield. The reaction proceeds via quinazolinone intermediate, which undergoes acid catalyzed cleavage to form deformylated product. (c) 2012 Elsevier Ltd. All rights reserved.

引用

页码：2222 / 2225

页数：4

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