Fetal brain lesions after sub-cutaneous inoculation of Zika virus in a pregnant nonhuman primate

被引：211

作者：

Waldorf, Kristina M. Adams ^{[1
]}

Stencel-Baerenwald, Jennifer E. ^{[2
,3
]}

Kapur, Raj P. ^{[4
,5
]}

Studholme, Colin ^{[6
,7
,8
]}

Boldenow, Erica ^{[6
,9
,20
]}

Vornhagen, Jay ^{[9
]}

Baldessari, Audrey ^{[11
]}

Dighe, Manjiri K. ^{[8
]}

Thiel, Jeff ^{[8
]}

Merillat, Sean ^{[9
]}

Armistead, Blair ^{[9
,10
]}

Tisoncik-Go, Jennifer ^{[2
,3
]}

Green, Richard R. ^{[2
,3
]}

Davis, Michael A. ^{[2
,3
]}

Dewey, Elyse C. ^{[2
,3
]}

Fairgrieve, Marian R. ^{[2
,3
]}

Gatenby, J. Christopher ^{[8
]}

Richards, Todd ^{[8
]}

Garden, Gwenn A. ^{[4
,12
]}

Diamond, Michael S. ^{[13
,14
,15
,16
]}

Juul, Sandra E. ^{[6
]}

Grant, Richard F. ^{[11
]}

Kuller, LaRene ^{[11
]}

Shaw, Dennis W. W. ^{[8
,17
]}

Ogle, Jason ^{[11
]}

Gough, G. Michael ^{[11
]}

Lee', Wonsok ^{[11
]}

English, Chris ^{[11
]}

Hevner, Robert F. ^{[18
,19
]}

Dobyns, William B. ^{[6
,19
]}

Gale, Michael, Jr. ^{[2
,3
]}

Rajagopa, Lakshmi ^{[6
,9
,10
]}

机构：

[1] Univ Washington, Dept Obstet & Gynecol, Seattle, WA 98195 USA

[2] Univ Washington, Dept Immunol, Seattle, WA 98195 USA

[3] Univ Washington, Ctr Innate Immun & Immune Dis, Seattle, WA 98195 USA

[4] Univ Washington, Dept Pathol, Seattle, WA 98195 USA

[5] Seattle Childrens Hosp, Dept Pathol, Seattle, WA USA

[6] Univ Washington, Dept Pediat, Seattle, WA 98195 USA

[7] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA

[8] Univ Washington, Dept Radiol, Seattle, WA 98195 USA

[9] Seattle Childrens Res Inst, Ctr Global Infect Dis Res, Seattle, WA USA

[10] Univ Washington, Dept Global Hlth, Seattle, WA 98195 USA

[11] Washington Natl Primate Res Ctr, Seattle, WA USA

[12] Univ Washington, Dept Neurol, Seattle, WA 98195 USA

[13] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA

[14] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA

[15] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO USA

[16] Washington Univ, Sch Med, Ctr Human Immunol & Immunotherapy Programs, St Louis, MO USA

[17] Seattle Childrens Hosp, Dept Radiol, Seattle, WA USA

[18] Univ Washington, Dept Neurol Surg, Seattle, WA 98195 USA

[19] Seattle Childrens Res Inst, Ctr Integrat Brain Res, Seattle, WA USA

[20] Calvin Coll, Dept Biol, Grand Rapids, MI 49506 USA

来源：

NATURE MEDICINE | 2016年 / 22卷 / 11期

基金：

美国国家卫生研究院;

关键词：

ENCEPHALITIS; INFECTION; MACAQUE; DAMAGE; CELLS;

D O I：

10.1038/nm.4193

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We describe the development of fetal brain lesions after Zika virus (ZIKV) inoculation in a pregnant pigtail macaque. Periventricular lesions developed within 10 d and evolved asymmetrically in the occipital-parietal lobes. Fetal autopsy revealed ZIKV in the brain and significant cerebral white matter hypoplasia, periventricular white matter gliosis, and axonal and ependymal injury. Our observation of ZIKV-associated fetal brain lesions in a nonhuman primate provides a model for therapeutic evaluation.

引用

页码：1256 / 1259

页数：4

共 19 条

[1]

Brasil R, 2016, N ENGL J MED

[2] Next-Generation Sequence Analysis of the Genome of RFHVMn, the Macaque Homolog of Kaposi's Sarcoma (KS)-Associated Herpesvirus, from a KS-Like Tumor of a Pig-Tailed Macaque [J].

Bruce, A. Gregory ;

Ryan, Jonathan T. ;

Thomas, Mathew J. ;

Peng, Xinxia ;

Grundhoff, Adam ;

Tsai, Che-Chung ;

Rose, Timothy M. .

JOURNAL OF VIROLOGY, 2013, 87 (24) :13676-13693

[3] ULTRASOUND MEASUREMENT OF FETAL GROWTH IN MACACA-NEMESTRINA [J].

CONRAD, S ;

HA, J ;

LOHR, C ;

SACKETT, G .

AMERICAN JOURNAL OF PRIMATOLOGY, 1995, 36 (01) :15-35

[4] The Brazilian Zika virus strain causes birth defects in experimental models [J].

Cugola, Fernanda R. ;

Fernandes, Isabella R. ;

Russo, Fabiele B. ;

Freitas, Beatriz C. ;

Dias, Joao L. M. ;

Guimaraes, Katia P. ;

Benazzato, Cecilia ;

Almeida, Nathalia ;

Pignatari, Graciela C. ;

Romero, Sarah ;

Polonio, Carolina M. ;

Cunha, Isabela ;

Freitas, Carla L. ;

Brandao, Wesley N. ;

Rossato, Cristiano ;

Andrade, David G. ;

Faria, Daniele de P. ;

Garcez, Alexandre T. ;

Buchpigel, Carlos A. ;

Braconi, Carla T. ;

Mendes, Erica ;

Sall, Amadou A. ;

Zanotto, Paolo M. de A. ;

Peron, Jean Pierre S. ;

Muotri, Alysson R. ;

Beltrao-Braga, Patricia C. B. .

NATURE, 2016, 534 (7606) :267-+

[5] Zika Virus Infection with Prolonged Maternal Viremia and Fetal Brain Abnormalities [J].

Driggers, R. W. ;

Ho, C. -Y. ;

Korhonen, E. M. ;

Kuivanen, S. ;

Jaaskelainen, A. J. ;

Smura, T. ;

Rosenberg, A. ;

Hill, D. A. ;

DeBiasi, R. L. ;

Vezina, G. ;

Timofeev, J. ;

Rodriguez, F. J. ;

Levanov, L. ;

Razak, J. ;

Iyengar, P. ;

Hennenfent, A. ;

Kennedy, R. ;

Lanciotti, R. ;

du Plessis, A. ;

Vapalahti, O. .

NEW ENGLAND JOURNAL OF MEDICINE, 2016, 374 (22) :2142-2151

[6] A rhesus macaque model of Asian-lineage Zika virus infection [J].

Dudley, Dawn M. ;

Aliota, Matthew T. ;

Mohr, Emma L. ;

Weiler, Andrea M. ;

Lehrer-Brey, Gabrielle ;

Weisgrau, Kim L. ;

Mohns, Mariel S. ;

Breitbach, Meghan E. ;

Rasheed, Mustafa N. ;

Newman, Christina M. ;

Gellerup, Dane D. ;

Moncla, Louise H. ;

Post, Jennifer ;

Schultz-Darken, Nancy ;

Schotzko, Michele L. ;

Hayes, Jennifer M. ;

Eudailey, Josh A. ;

Moody, M. Anthony ;

Permar, Sallie R. ;

O'Connor, Shelby L. ;

Rakasz, Eva G. ;

Simmons, Heather A. ;

Capuano, Saverio ;

Golos, Thaddeus G. ;

Osorio, Jorge E. ;

Friedrich, Thomas C. ;

O'Connor, David H. .

NATURE COMMUNICATIONS, 2016, 7

[7] NEONATAL ECHOVIRUS ENCEPHALITIS WITH WHITE MATTER NECROSIS [J].

HADDAD, J ;

MESSER, J ;

GUT, JP ;

CHAIGNE, D ;

CHRISTMANN, D ;

WILLARD, D .

NEUROPEDIATRICS, 1990, 21 (04) :215-217

[8] Damage to the Immature Optic Radiation Causes Severe Reduction of the Retinal Nerve Fiber Layer, Resulting in Predictable Visual Field Defects [J].

Lennartsson, Finn ;

Nilsson, Maria ;

Flodmark, Olof ;

Jacobson, Lena .

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2014, 55 (12) :8278-8288

[9] MR imaging of herpes simplex type I encephalitis in infants and young children: A separate pattern of findings [J].

Leonard, JR ;

Moran, CJ ;

Cross, DT ;

Wippold, FJ ;

Schlesinger, Y ;

Storch, GA .

AMERICAN JOURNAL OF ROENTGENOLOGY, 2000, 174 (06) :1651-1655

[10] Oral Susceptibility of Singapore Aedes (Stegomyia) aegypti (Linnaeus) to Zika Virus [J].

Li, MeiZhi Irene ;

Wong, Pei Sze Jeslyn ;

Ng, Lee Ching ;

Tan, Cheong Huat .

PLOS NEGLECTED TROPICAL DISEASES, 2012, 6 (08)

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