Fetal brain lesions after sub-cutaneous inoculation of Zika virus in a pregnant nonhuman primate

被引：209

作者：

Waldorf, Kristina M. Adams ^{[1
]}

Stencel-Baerenwald, Jennifer E. ^{[2
,3
]}

Kapur, Raj P. ^{[4
,5
]}

Studholme, Colin ^{[6
,7
,8
]}

Boldenow, Erica ^{[6
,9
,20
]}

Vornhagen, Jay ^{[9
]}

Baldessari, Audrey ^{[11
]}

Dighe, Manjiri K. ^{[8
]}

Thiel, Jeff ^{[8
]}

Merillat, Sean ^{[9
]}

Armistead, Blair ^{[9
,10
]}

Tisoncik-Go, Jennifer ^{[2
,3
]}

Green, Richard R. ^{[2
,3
]}

Davis, Michael A. ^{[2
,3
]}

Dewey, Elyse C. ^{[2
,3
]}

Fairgrieve, Marian R. ^{[2
,3
]}

Gatenby, J. Christopher ^{[8
]}

Richards, Todd ^{[8
]}

Garden, Gwenn A. ^{[4
,12
]}

Diamond, Michael S. ^{[13
,14
,15
,16
]}

Juul, Sandra E. ^{[6
]}

Grant, Richard F. ^{[11
]}

Kuller, LaRene ^{[11
]}

Shaw, Dennis W. W. ^{[8
,17
]}

Ogle, Jason ^{[11
]}

Gough, G. Michael ^{[11
]}

Lee', Wonsok ^{[11
]}

English, Chris ^{[11
]}

Hevner, Robert F. ^{[18
,19
]}

Dobyns, William B. ^{[6
,19
]}

Gale, Michael, Jr. ^{[2
,3
]}

Rajagopa, Lakshmi ^{[6
,9
,10
]}

机构：

[1] Univ Washington, Dept Obstet & Gynecol, Seattle, WA 98195 USA

[2] Univ Washington, Dept Immunol, Seattle, WA 98195 USA

[3] Univ Washington, Ctr Innate Immun & Immune Dis, Seattle, WA 98195 USA

[4] Univ Washington, Dept Pathol, Seattle, WA 98195 USA

[5] Seattle Childrens Hosp, Dept Pathol, Seattle, WA USA

[6] Univ Washington, Dept Pediat, Seattle, WA 98195 USA

[7] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA

[8] Univ Washington, Dept Radiol, Seattle, WA 98195 USA

[9] Seattle Childrens Res Inst, Ctr Global Infect Dis Res, Seattle, WA USA

[10] Univ Washington, Dept Global Hlth, Seattle, WA 98195 USA

[11] Washington Natl Primate Res Ctr, Seattle, WA USA

[12] Univ Washington, Dept Neurol, Seattle, WA 98195 USA

[13] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA

[14] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA

[15] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO USA

[16] Washington Univ, Sch Med, Ctr Human Immunol & Immunotherapy Programs, St Louis, MO USA

[17] Seattle Childrens Hosp, Dept Radiol, Seattle, WA USA

[18] Univ Washington, Dept Neurol Surg, Seattle, WA 98195 USA

[19] Seattle Childrens Res Inst, Ctr Integrat Brain Res, Seattle, WA USA

[20] Calvin Coll, Dept Biol, Grand Rapids, MI 49506 USA

来源：

NATURE MEDICINE | 2016年 / 22卷 / 11期

基金：

美国国家卫生研究院;

关键词：

ENCEPHALITIS; INFECTION; MACAQUE; DAMAGE; CELLS;

D O I：

10.1038/nm.4193

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We describe the development of fetal brain lesions after Zika virus (ZIKV) inoculation in a pregnant pigtail macaque. Periventricular lesions developed within 10 d and evolved asymmetrically in the occipital-parietal lobes. Fetal autopsy revealed ZIKV in the brain and significant cerebral white matter hypoplasia, periventricular white matter gliosis, and axonal and ependymal injury. Our observation of ZIKV-associated fetal brain lesions in a nonhuman primate provides a model for therapeutic evaluation.

引用

页码：1256 / 1259

页数：4

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