Effect of Ultrasound-Guided Radiofrequency Ablation in Incompletely Treated Hepatocellular Carcinoma after Transcatheter Arterial Chemoembolization

被引:8
作者
Chang, Nam Kyu [4 ,5 ]
Shin, Sang Soo [1 ,2 ,3 ]
Kim, Jin Woong [4 ,5 ]
Kim, Hyung Jun [4 ,5 ]
Jeong, Yong Yeon [4 ,5 ]
Heo, Suk Hee [4 ,5 ]
Kim, Jae Kyu [1 ]
Kang, Heoung Keun [4 ,5 ]
机构
[1] Chonnam Natl Univ, Sch Med, Dept Radiol, Kwangju 501757, South Korea
[2] Chonnam Natl Univ, Sch Med, Ctr Aging & Geriatr, Kwangju 501757, South Korea
[3] Chonnam Natl Univ Hosp, Kwangju 501757, South Korea
[4] Chonnam Natl Univ, Hwasun Hosp, Hwasun 519809, South Korea
[5] Chonnam Natl Univ, Sch Med, Dept Radiol, Hwasun 519809, South Korea
关键词
Hepatocellular carcinoma; Radiofrequency ablation; Transcatheter arterial chemoembolization; PERCUTANEOUS ETHANOL INJECTION; RANDOMIZED CONTROLLED-TRIAL; THERMAL ABLATION; HEPATIC-TUMORS; TRANSARTERIAL CHEMOEMBOLIZATION; LIPIODOL CHEMOEMBOLIZATION; PARTIAL-HEPATECTOMY; THERAPY; CIRRHOSIS; EMBOLIZATION;
D O I
10.3348/kjr.2012.13.S1.S104
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Objective: To evaluate the effectiveness of ultrasound-guided radiofrequency (RF) ablation in patients with incompletely treated hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolization (TACE) and to evaluate possible prognostic factors for this therapy. Subjects and Methods: Thirty nine patients with incompletely treated single HCC (<= 5 cm) after TACE were treated with RF ablation. All patients were evaluated for complete tumor ablation rate, local recurrence-free rate, overall survival rate, and complications. Local recurrence-free rate and overall survival rate were calculated using the Kaplan-Meier method. The possible prognostic factors of local recurrence-free rate and survival rate were analyzed using Cox proportional-hazards regression model. Results: The complete tumor ablation rate was 92.3%. Local recurrence-free rates for 1-, 2-, 3-, and 5-years were 81.7%, 63.1%, 53.6%, and 35.7%, respectively. One-, 2-, 3-, and 5-year overall survival rates were 96.9%, 82.9%, 67.8%, and 48.4%, respectively. Among prognostic factors included in the analysis, only tumor diameter (<= 2 cm versus > 2 cm) was statistically significant in terms of predicting local recurrence. Complications were observed in two patients, one with liver abscess and the other with portal venous thrombosis. Conclusion: Ultrasound-guided RF ablation could be effective and safe in treating incompletely treated HCC after TACE. The diameter of HCC was a significant prognostic factor for local recurrence.
引用
收藏
页码:S104 / S111
页数:8
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