Waldenstrom Macroglobulinemia: Mechanisms of Disease Progression and Current Therapies

被引：5

作者：

Boutilier, Ava J. ^{[1
]}

Huang, Lina ^{[2
]}

Elsawa, Sherine F. ^{[1
]}

机构：

[1] Univ New Hampshire, Dept Mol Cellular & Biomed Sci, Durham, NH 03824 USA

[2] Phillips Exeter Acad, Exeter, NH 03833 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 19期

关键词：

Waldenstrom macroglobulinemia; B-cell lymphoma; non-Hodgkin's; bone marrow microenvironment; disease progression; targeted therapy; NF-KAPPA-B; BONE-MARROW MICROENVIRONMENT; PHASE-II TRIAL; HYPOXIA PROMOTES DISSEMINATION; EPHRIN-A1; MESSENGER-RNA; SPLEEN TYROSINE KINASE; MULTIPLE-MYELOMA; MYD88; L265P; IN-VITRO; INHIBITOR EVEROLIMUS;

D O I：

10.3390/ijms231911145

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Waldenstrom macroglobulinemia is an indolent, B-cell lymphoma without a known cure. The bone marrow microenvironment and cytokines both play key roles in Waldenstrom macroglobulinemia (WM) tumor progression. Only one FDA-approved drug exists for the treatment of WM, Ibrutinib, but treatment plans involve a variety of drugs and inhibitors. This review explores avenues of tumor progression and targeted drug therapy that have been investigated in WM and related B-cell lymphomas.

引用

页数：20

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