Complete complex conjugate resolved heterodyne swept-source optical coherence tomography using a dispersive optical delay line

被引:13
作者
Dhalla, Al-Hafeez [1 ]
Izatt, Joseph A. [1 ]
机构
[1] Duke Univ, Dept Biomed Engn, Durham, NC 27708 USA
来源
BIOMEDICAL OPTICS EXPRESS | 2011年 / 2卷 / 05期
基金
美国国家卫生研究院;
关键词
TO-NOISE RATIO; HIGH-SPEED; DEPTH-DEGENERACY; RANGE; RESOLUTION; AMBIGUITY; PHASE; COMPENSATION; PERFORMANCE; REMOVAL;
D O I
10.1364/BOE.2.001218
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Swept-source optical coherence tomography (SSOCT) provides a substantial sensitivity advantage over its time-domain counterpart, but suffers from a reduced imaging depth range due to sensitivity falloff and complex conjugate ambiguity. Heterodyne complex conjugate-resolved SSOCT (HCCR-SSOCT) has been previously demonstrated as a technique to completely resolve the complex conjugate ambiguity, effectively doubling the falloff limited imaging depth, without the reduction in imaging speed associated with other CCR techniques. However, previous implementations of this technique have employed expensive and lossy optical modulators to provide the required differential phase modulation. In this paper, we demonstrate the use of a dispersive optical delay line (D-ODL) as the reference arm of an OCT system to realize HCCR-SSOCT. This technique maintains the existing advantages of HCCR-SSOCT in that it completely resolves the complex conjugate artifact and does not reduce imaging speed, while conferring the additional advantages of being low cost, maintaining system sensitivity and resolution, not requiring any additional signal processing, and working at all wavelengths and imaging speeds. The D-ODL also allows for hardware correction of unbalanced dispersion in the reference and sample arm, adding further flexibility to system design. We demonstrate the technique using an SSOCT system operating at 100kHz with a central wavelength of 1040nm. Falloff measurements performed using a standard OCT configuration and the proposed D-ODL demonstrate a doubling of the effective imaging range with no sensitivity or resolution penalty. Feasibility of the technique for in vivo imaging was demonstrated by imaging the ocular anterior segments of healthy human volunteers. (C) 2011 Optical Society of America
引用
收藏
页码:1218 / 1232
页数:15
相关论文
共 33 条
  • [1] Use of a scanner to modulate spatial interferograms for in vivo full-range Fourier-domain optical coherence tomography
    An, Lin
    Wang, Ruikang K.
    [J]. OPTICS LETTERS, 2007, 32 (23) : 3423 - 3425
  • [2] Heterodyne Fourier domain optical coherence tomography for full range probing with high axial resolution
    Bachmann, AH
    Leitgeb, RA
    Lasser, T
    [J]. OPTICS EXPRESS, 2006, 14 (04): : 1487 - 1496
  • [3] Spectrally balanced detection for optical frequency domain imaging
    Chen, Yueli
    de Bruin, Daniel M.
    Kerbage, Charles
    de Boer, Johannes F.
    [J]. OPTICS EXPRESS, 2007, 15 (25) : 16390 - 16399
  • [4] Sensitivity advantage of swept source and Fourier domain optical coherence tomography
    Choma, MA
    Sarunic, MV
    Yang, CH
    Izatt, JA
    [J]. OPTICS EXPRESS, 2003, 11 (18): : 2183 - 2189
  • [5] Heterodyne swept-source optical coherence tomography for complete complex conjugate ambiguity removal
    Davis, AM
    Choma, MA
    Izatt, JA
    [J]. JOURNAL OF BIOMEDICAL OPTICS, 2005, 10 (06)
  • [6] Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography
    de Boer, JF
    Cense, B
    Park, BH
    Pierce, MC
    Tearney, GJ
    Bouma, BE
    [J]. OPTICS LETTERS, 2003, 28 (21) : 2067 - 2069
  • [7] High resolution in vivo intra-arterial imaging with optical coherence tomography
    Fujimoto, JG
    Boppart, SA
    Tearney, GJ
    Bouma, BE
    Pitris, C
    Brezinski, ME
    [J]. HEART, 1999, 82 (02) : 128 - 133
  • [8] Performance of reduced bit-depth acquisition for optical frequency domain imaging
    Goldberg, Brian D.
    Vakoc, Benjamin J.
    Oh, Wang-Yuhl
    Suter, Melissa J.
    Waxman, Sergio
    Freilich, Mark I.
    Bouma, Brett E.
    Tearney, Guillermo J.
    [J]. OPTICS EXPRESS, 2009, 17 (19): : 16957 - 16968
  • [9] High speed full range complex spectral domain optical coherence tomography
    Götzinger, E
    Pircher, M
    Leitgeb, RA
    Hitzenberger, CK
    [J]. OPTICS EXPRESS, 2005, 13 (02): : 583 - 594
  • [10] OPTICAL COHERENCE TOMOGRAPHY OF THE HUMAN RETINA
    HEE, MR
    IZATT, JA
    SWANSON, EA
    HUANG, D
    SCHUMAN, JS
    LIN, CP
    PULIAFITO, CA
    FUJIMOTO, JG
    [J]. ARCHIVES OF OPHTHALMOLOGY, 1995, 113 (03) : 325 - 332