A nationwide survey of the influence of month of birth on the risk of developing multiple sclerosis in Sweden and Iceland

被引:8
|
作者
Eliasdottir, Olof [1 ]
Hildeman, Anders [2 ,3 ]
Longfils, Marco [2 ,3 ]
Nerman, O. [2 ,3 ]
Lycke, J. [1 ]
机构
[1] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Clin Neurosci, Blaa Straket 7, S-41345 Gothenburg, Sweden
[2] Chalmers Univ Technol, Dept Math Sci, Gothenburg, Sweden
[3] Univ Gothenburg, Gothenburg, Sweden
关键词
Multiple sclerosis; Month of birth; Risk factors; Epidemiology; Sweden; Iceland; VITAMIN-D; ULTRAVIOLET-RADIATION; POPULATION; PREVALENCE; EXPOSURE;
D O I
10.1007/s00415-017-8665-y
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Previous studies have shown that the risk of multiple sclerosis (MS) is associated with season of birth with a higher proportion of MS patients being born in spring. However, this relationship has recently been questioned and may be due to confounding factors. Our aim was to assess the influence from season or month of birth on the risk of developing MS in Sweden and Iceland. Information about month of birth, gender, and phenotype of MS for patients born 1940-1996 was retrieved from the Swedish MS registry (SMSR), and their place of birth was retrieved from the Swedish Total Population Registry (TPR). The corresponding information was retrieved from medical journals of Icelandic MS patients born 1981-1996. The control groups consisted of every person born in Sweden 1940-1996, their gender and county of birth (TPR), and in Iceland all persons born between 1981 and 1996 and their gender (Statistics Iceland). We calculated the expected number of MS patients born during each season and in every month and compared it with the observed number. Adjustments were made for gender, birth year, and county of birth. We included 12,020 Swedish and 108 Icelandic MS patients in the analyses. There was no significant difference between expected and observed MS births related to season or month of birth in Sweden or Iceland. This was even the results before adjustments were made for birth year and birth place. No significant differences were found in subgroup analyses including data of latitude of birth, gender, clinical phenotype, and MS onset of 30 years or less. Our results do not support the previously reported association between season or month of birth and MS risk. Analysis of birth place and birth year as possible confounding factors showed no major influence of them on the seasonal MS risk in Sweden and Iceland.
引用
收藏
页码:108 / 114
页数:7
相关论文
共 50 条
  • [41] The fourth nationwide survey of multiple sclerosis in Japan: MRI characteristics of Japanese multiple sclerosis
    Osoegawafa, M.
    Fukazawa, T.
    Fujihara, K.
    Matsui, M.
    Kohriyama, T.
    Kikuchi, S.
    Doyu, M.
    Yamamura, T.
    Itoyama, Y.
    Saida, T.
    Ochi, H.
    Sakata, K.
    Kira, J.
    JOURNAL OF NEUROIMMUNOLOGY, 2006, 178 : 93 - 93
  • [42] Prevalence of multiple sclerosis in French farmers: a nationwide survey
    Van Bockstael, V
    Gosselin, S
    Vukusic, S
    Confavreux, C
    MULTIPLE SCLEROSIS, 2004, 10 (7032): : S156 - S156
  • [43] Cardiovascular disease in patients with multiple sclerosis: a nationwide cohort study in Sweden
    Piehl, F.
    Castelo-Branco, A.
    Chiesa, F.
    Conte, S.
    Rosenlund, M.
    Lee, S.
    Minton, N.
    Niemcryk, S.
    Lindholm, A.
    Montgomery, S.
    MULTIPLE SCLEROSIS JOURNAL, 2019, 25 : 49 - 50
  • [44] HLA-DRB1 and month of birth in multiple sclerosis
    Ramagopalan, S. V.
    Link, J.
    Byrnes, J. K.
    Dyment, D. A.
    Giovannoni, G.
    Hintzen, R. Q.
    Sundqvist, E.
    Kockum, I.
    Smestad, C.
    Lic, B. A.
    Harbo, H. F.
    Padyukov, L.
    Alfredsson, L.
    Olsson, T.
    Sadovnick, A. D.
    Hillert, J.
    Ebers, G. C.
    NEUROLOGY, 2009, 73 (24) : 2107 - 2111
  • [45] Confounding underlies the apparent month of birth effect in multiple sclerosis
    Fiddes, Barnaby
    Wason, James
    Kemppinen, Anu
    Ban, Maria
    Compston, Alastair
    Sawcer, Stephen
    ANNALS OF NEUROLOGY, 2013, 73 (06) : 714 - 720
  • [46] Breastfeeding and risk of developing multiple sclerosis
    Baldin, E.
    Daltveit, A. -K.
    Riise, T.
    Pugliatti, M.
    EUROPEAN JOURNAL OF NEUROLOGY, 2019, 26 : 330 - 330
  • [47] The fourth nationwide survey of multiple sclerosis in Japan discloses anticipation of age at onset in multiple sclerosis
    Osoegawa, M
    Fukazawa, T
    Fujihara, K
    Matsui, M
    Kohriyama, T
    Kikuchi, S
    Doyu, M
    Yamamura, T
    Sakata, K
    Kira, J
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 2005, 238 : S68 - S69
  • [48] Month of birth in multiple sclerosis with and without longitudinally extensive spinal cord lesions: A study of a Japanese national survey
    Araki, Yasukiyo
    Kinoshita, Masako
    Motoyama, Rie
    Matsushita, Takuya
    Nakagawa, Masanori
    Kira, Jun-ichi
    Tanaka, Masami
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 2013, 330 (1-2) : 67 - 70
  • [49] No Effect of Birth Weight on the Risk of Multiple Sclerosis
    Ramagopalan, Sreeram V.
    Herrera, Blanca M.
    Valdar, William
    Dyment, David A.
    Orton, Sarah-Michelle
    Yee, Irene M.
    Criscuoli, Maria
    Atkins, Kevin
    Ebers, George C.
    Sadovnick, A. Dessa
    NEUROEPIDEMIOLOGY, 2008, 31 (03) : 181 - 184
  • [50] Is Season of Birth Important for Multiple Sclerosis Risk?
    Graves, Jennifer S.
    JAMA NEUROLOGY, 2016, 73 (08) : 912 - 913