Scaffold hybridization in generation of indenoindolones as anticancer agents that induce apoptosis with cell cycle arrest at G2/M phase

被引：59

作者：

Kashyap, Maneesh ^{[2
]}

Das, Dipon ^{[1
]}

Preet, Ranjan ^{[1
]}

Mohapatra, Purusottam ^{[1
]}

Satapathy, Shakti Ranjan ^{[1
]}

Siddharth, Sumit ^{[3
]}

Kundu, Chanakya N. ^{[1
]}

Guchhait, Sankar K. ^{[2
]}

机构：

[1] KIIT Univ, Sch Biotechnol, Bhubaneswar 751024, Orissa, India

[2] NIPER, Mohali 160062, Punjab, India

[3] Inst Life Sci, Bhubaneswar 751023, Orissa, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 07期

关键词：

Indenoindolones; Hybrid; Anticancer; Cell cycle; Apoptosis; TOPOISOMERASE-II; HYBRID MOLECULES; FACILE SYNTHESIS; DRUG DISCOVERY; DNA; DERIVATIVES; AZATOXIN; INHIBITION; RESISTANCE; OXIDATION;

D O I：

10.1016/j.bmcl.2012.02.007

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Scaffold hybridization of several natural and synthetic anticancer leads led to the consideration of indenoindolones as potential novel anticancer agents. A series of these compounds were prepared by a diversity-feasible synthetic method. They were found to possess anticancer activities with higher potency compared to etoposide and 5-fluorouracil in kidney cancer cells (HEK 293) and low toxicity to corresponding normal cells (Vero). They exerted apoptotic effect with blocking of cell cycle at G2/M phase. (C) 2012 Elsevier Ltd. All rights reserved.

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页码：2474 / 2479

页数：6

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