Etiologies of severe acute respiratory infection (SARI) and misdiagnosis of influenza in Indonesia, 2013-2016

被引：13

作者：

Aman, Abu Tholib ^{[1
,2
]}

Wibawa, Tri ^{[1
,2
]}

Kosasih, Herman ^{[2
]}

Asdie, Rizka Humardewayanti ^{[2
,3
]}

Safitri, Ida ^{[2
,4
]}

Intansari, Umi Solekhah ^{[2
,5
]}

Mawarti, Yuli ^{[1
,2
]}

Sudarmono, Pratiwi ^{[6
]}

Arif, Mansyur ^{[7
]}

Puspitasari, Dwiyanti ^{[8
]}

Alisjahbana, Bachti ^{[9
]}

Parwati, Ketut Tuti Merati ^{[10
,11
]}

Gasem, Muhammad Hussein ^{[12
]}

Lokida, Dewi ^{[13
]}

Lukman, Nurhayati ^{[2
]}

Hartono, Teguh Sarry ^{[2
,14
]}

Mardian, Yan ^{[2
]}

Liang, C. Jason ^{[15
]}

Siddiqui, Sophia ^{[2
,15
]}

Karyana, Muhammad ^{[2
,16
]}

Lau, Chuen-Yen ^{[2
,15
]}

机构：

[1] Univ Gadjah Mada, Dept Microbiol, Fac Med Publ Hlth & Nursing, Dr Sardjito Hosp, Yogyakarta, Indonesia

[2] Indonesia Res Partnership Infect Dis INA RESPOND, Jakarta, Indonesia

[3] Univ Gadjah Mada, Dept Internal Med, Fac Med Publ Hlth & Nursing, Dr Sardjito Hosp, Yogyakarta, Indonesia

[4] Univ Gadjah Mada, Dept Pediat, Fac Med Publ Hlth & Nursing, Dr Sardjito Hosp, Yogyakarta, Indonesia

[5] Univ Gadjah Mada, Dept Clin Pathol, Fac Med Publ Hlth & Nursing, Dr Sardjito Hosp, Yogyakarta, Indonesia

[6] Univ Indonesia, Cipto Mangunkusumo Hosp, Fac Med, Jakarta, Indonesia

[7] Univ Hasanudin, Fac Med, Dr Wahidin Sudirohusodo Hosp, Makassar, Indonesia

[8] Univ Airlangga, Fac Med, Dr Soetomo Acad Gen Hosp, Surabaya, Indonesia

[9] Univ Padjadjaran, Fac Med, Dr Hasan Sadikin Hosp, Sumedang, Indonesia

[10] Udayana Univ, Med Fac, Denpasar, Indonesia

[11] Sanglah Gen Hosp, Denpasar, Indonesia

[12] Diponegoro Univ, Dr Kariadi Hosp, Semarang, Indonesia

[13] Tangerang Dist Hosp, Tangerang, Indonesia

[14] Sulianti Saroso Hosp, Jakarta, Indonesia

[15] NIAID, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

[16] Minist Hlth, Natl Inst Hlth Res & Dev NIHRD, Jakarta, Indonesia

来源：

INFLUENZA AND OTHER RESPIRATORY VIRUSES | 2021年 / 15卷 / 01期

关键词：

diagnostic accuracy; etiology; Indonesia; influenza; severe acute respiratory infection; CLINICAL CASE DEFINITIONS; HOSPITALIZED-PATIENTS; VIRUS-INFECTIONS; SURVEILLANCE; COMMUNITY; ILLNESS; DIAGNOSIS; PNEUMONIA; CHILDREN;

D O I：

10.1111/irv.12781

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Background Severe acute respiratory infection (SARI) accounts for a large burden of illness in Indonesia. However, epidemiology of SARI in tertiary hospitals in Indonesia is unknown. This study sought to assess the burden, clinical characteristics, and etiologies of SARI and concordance of clinical diagnosis with confirmed etiology. Methods Data and samples were collected from subjects presenting with SARI as part of the acute febrile Illness requiring hospitalization study (AFIRE). In tertiary hospitals, clinical diagnosis was ascertained from chart review. Samples were analyzed to determine the "true" etiology of SARI at hospitals and Indonesia Research Partnership on Infectious Diseases (INA-RESPOND) laboratory. Distribution and characteristics of SARI by true etiology and accuracy of clinical diagnosis were assessed. Results Four hundred and twenty of 1464 AFIRE subjects presented with SARI; etiology was identified in 242 (57.6%), including 121 (28.8%) viruses and bacteria associated with systemic infections, 70 (16.7%) respiratory bacteria and viruses other than influenza virus, and 51 (12.1%) influenza virus cases. None of these influenza patients were accurately diagnosed as having influenza during hospitalization. Conclusions Influenza was misdiagnosed among all patients presenting with SARI to Indonesian tertiary hospitals in the AFIRE study. Diagnostic approaches and empiric management should be guided by known epidemiology. Public health strategies to address the high burden of influenza should include broad implementation of SARI screening, vaccination programs, clinician education and awareness campaigns, improved diagnostic capacity, and support for effective point-of-care tests.

引用

页码：34 / 44

页数：11

共 42 条

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