Construction of an Immunogenomic Risk Score for Prognostication in Colon Cancer

被引：13
作者：
Zhang, Han [1 ,2 ]
Qin, Chuan [3 ]
Gan, Hua [1 ]
Guo, Xiong [1 ]
Zhang, Li [2 ]
机构：
[1] Chongqing Med Univ, Clin Med Coll 1, Chongqing, Peoples R China
[2] Chongqing Univ, Three Gorges Hosp, Dept Digest Oncol, Chongqing, Peoples R China
[3] Chongqing Univ, Three Gorges Hosp, Dept Gastrointestinal Surg, Chongqing, Peoples R China
来源：
FRONTIERS IN GENETICS | 2020年 / 11卷
关键词：
immune-related genes; immune system; colon cancer; prognostication; biomarkers; AMERICAN JOINT COMMITTEE; WEB SERVER; ADJUVANT CHEMOTHERAPY; COLORECTAL-CARCINOMA; GROWTH-FACTOR; TUMOR ESCAPE; 7TH EDITION; STAGE-II; SURVIVAL; CELLS;
D O I：
10.3389/fgene.2020.00499
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Immune-related genes (IRGs) play regulatory roles in the immune system and are involved in the initiation and progression of colon cancer. This study aimed to develop an immunogenomic risk score for predicting survival outcomes among colon cancer patients. We analyzed the expressions of IRGs in colon specimens and discovered 484 differentially expressed IRGs when we compared specimens from colon cancer and adjacent normal tissue. Univariate Cox regression analyses were performed to identify 26 IRGs that were associated with survival. A Cox proportional hazards model with a lasso penalty identified five optimal IRGs for constructing the immunogenomic risk score (CD1B, XCL1, PLCG2, NGF, and OXTR). The risk score had good performance in predicting overall survival among patients with colon cancer and was correlated with the amount of tumor-infiltrating immune cells. Our findings suggest that the immunogenomic risk score may be useful for prognostication in colon cancer cases. Furthermore, the five IRGs included in the risk score might be useful targets for investigating the initiation of colon cancer and designing personalized treatments.
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页数：13
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