mRNA-1273 and BNT162b2 mRNA vaccines have reduced neutralizing activity against the SARS-CoV-2 omicron variant

被引：127

作者：

Edara, Venkata-Viswanadh ^{[1
,2
,8
]}

Manning, Kelly E. ^{[1
,2
,8
]}

Ellis, Madison ^{[1
,2
,8
]}

Lai, Lilin ^{[1
,2
,8
]}

Moore, Kathryn M. ^{[1
,2
,8
]}

Foster, Stephanie L. ^{[1
,2
,8
]}

Floyd, Katharine ^{[1
,2
,8
]}

Davis-Gardner, Meredith E. ^{[1
,2
,8
]}

Mantus, Grace ^{[1
,2
,4
]}

Nyhoff, Lindsay E. ^{[1
,2
,4
]}

Bechnak, Sarah ^{[4
]}

Alaaeddine, Ghina ^{[4
]}

Naji, Amal ^{[4
]}

Samaha, Hady ^{[4
]}

Lee, Matthew ^{[4
]}

Bristow, Laurel ^{[4
]}

Gagne, Matthew ^{[6
]}

Roberts-Torres, Jesmine ^{[6
]}

Henry, Amy R. ^{[6
]}

Godbole, Sucheta ^{[6
]}

Grakoui, Arash ^{[2
,3
,4
,8
]}

Saxton, Marybeth ^{[4
]}

Piantadosi, Anne ^{[4
,7
]}

Waggoner, Jesse J. ^{[4
]}

Douek, Daniel C. ^{[6
]}

Rouphael, Nadine ^{[4
,5
]}

Wrammert, Jens ^{[1
,2
]}

Suthar, Mehul S. ^{[1
,2
,3
,8
]}

机构：

[1] Emory Univ, Ctr Childhood Infect & Vaccines Childrens Healthc, Dept Pediat, Sch Med, Atlanta, GA 30322 USA

[2] Emory Univ, Emory Vaccine Ctr, Atlanta, GA 30322 USA

[3] Emory Univ, Dept Microbiol & Immunol, Atlanta, GA 30322 USA

[4] Emory Univ, Div Infect Dis, Dept Med, Sch Med, Atlanta, GA USA

[5] Emory Univ, Hope Clin Emory Vaccine Ctr, Decatur, GA USA

[6] Natl Inst Hlth, Natl Inst Allergy & Infect Dis, Vaccine Res Ctr, Rockville, MD USA

[7] Emory Univ, Dept Pathol & Lab Med, Sch Med, Atlanta, GA USA

[8] Yerkes Natl Primate Res Ctr, Atlanta, GA 30329 USA

来源：

CELL REPORTS MEDICINE | 2022年 / 3卷 / 02期

基金：

美国国家卫生研究院;

关键词：

antibody; B.1.1.529; booster dose; live-virus; mRNA vaccines; neutralization assay; Omicron; Omicron variant; SARS-CoV-2; vaccine induced immunity;

D O I：

10.1016/j.xcrm.2022.100529

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) omicron variant emerged in November 2021 and consists of several mutations within the spike. We use serum from mRNA-vaccinated individuals to measure neutralization activity against omicron in a live-virus assay. At 2-4 weeks after a primary series of vaccinations, we observe a 30-fold reduction in neutralizing activity against omicron. Six months after the initial two-vaccine doses, sera from naive vaccinated subjects show no neutralizing activity against omicron. In contrast, COVID-19-recovered individuals 6 months after receiving the primary series of vaccinations show a 22-fold reduction, with the majority of the subjects retaining neutralizing antibody responses. In naive individuals following a booster shot (third dose), we observe a 14-fold reduction in neutralizing activity against omicron, and over 90% of subjects show neutralizing activity. These findings show that a third dose is required to provide robust neutralizing antibody responses against the omicron variant.

引用

页数：7

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