RASSF1A promoter methylation correlates development, progression, and poor cancer-specific survival of renal cell carcinoma: trial sequential analysis

被引:1
作者
Zhuang, Qianfeng [1 ]
Chen, Zhen [1 ]
Shen, Jie [1 ]
Fan, Min [1 ]
Xue, Dong [1 ]
Lu, Hao [1 ]
Xu, Renfang [1 ]
He, Xiaozhou [1 ]
机构
[1] Soochow Univ, Dept Urol, Affiliated Hosp 3, 185 Juqian St, Changzhou 213003, Peoples R China
来源
ONCOTARGETS AND THERAPY | 2019年 / 12卷
基金
中国博士后科学基金; 美国国家科学基金会;
关键词
RAS association domain family protein 1A; methylation; survival; clinical features; TUMOR-SUPPRESSOR GENE; CLEAR-CELL; DNA HYPERMETHYLATION;
D O I
10.2147/OTT.S183142
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Background: This meta-analysis evaluated the clinicopathologic and prognostic significance of RASSP1A promoter methylation in renal cell carcinoma (RCC). Materials and methods: The ORs or HRs and their 95% CIs were calculated. Trial sequential analysis was conducted. Results: Twenty-two articles that included 1,421 patients with RCC and 724 controls were identified. RASSF1A promoter methylation correlated with RCC in tissue, blood, and urine samples. On multivariate analysis, RASSF1A promoter methylation was associated with tumor grade (grade 3-4 vs 1-2: OR=3.59), clinical stage (stage 3-4 vs 1-2: OR=2.15), T classification (pT2-4 vs pT1: OR=2.66), histologic subtypes (papillary vs clear cell: OR=2.91), and cancer-specific survival (HR=1.78), but it was not linked to age, gender, lymph node status, distant metastasis, or overall survival. The Cancer Genome Atlas data also showed that RASSF1A methylation was significantly more likely to be seen in papillary vs clear-cell RCC (OR=23.19). Conclusion: RASSP1A promoter methylation may be associated with the development and progression of RCC, as well as poor cancer-specific survival. Methylation was more frequent in papillary vs clear-cell RCC. More studies are needed to confirm these findings in blood or urine samples.
引用
收藏
页码:119 / 134
页数:16
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