Decreased neurotrophin-3 expression in skeletal muscles of streptozotocin-induced diabetic rats

被引：27

作者：

Ihara, C ^{[1
]}

Shimatsu, A ^{[1
]}

Mizuta, H ^{[1
]}

Murabe, H ^{[1
]}

Nakamura, Y ^{[1
]}

Nakao, K ^{[1
]}

机构：

[1] KYOTO UNIV, DEPT MED & CLIN SCI, KYOTO, JAPAN

来源：

NEUROPEPTIDES | 1996年 / 30卷 / 04期

关键词：

D O I：

10.1016/S0143-4179(96)90018-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The expression of neurotrophin-3 (NT-3) in skeletal muscles was measured in rats with streptozotocin (STZ)- induced diabetes using Northern blot analysis. At 6 weeks after STZ induction of diabetes, the NT-3 mRNA level in the quadriceps and gastrocnemius muscles was decreased by 45 and 77%, respectively, compared with that in age-matched controls. Since NT-3 is considered to be essential for the maintenance of spinal proprioceptive afferent neurons, decreased NT-3 expression in target tissues would impair the integrity of afferent neurons and might be an earlier marker in the sensory neuronal damage observed in diabetes mellitus.

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页码：309 / 312

页数：4

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