Decreased neurotrophin-3 expression in skeletal muscles of streptozotocin-induced diabetic rats

被引：27
|
作者：
Ihara, C [1 ]
Shimatsu, A [1 ]
Mizuta, H [1 ]
Murabe, H [1 ]
Nakamura, Y [1 ]
Nakao, K [1 ]
机构：
[1] KYOTO UNIV, DEPT MED & CLIN SCI, KYOTO, JAPAN
来源：
NEUROPEPTIDES | 1996年 / 30卷 / 04期
关键词：
D O I：
10.1016/S0143-4179(96)90018-9
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The expression of neurotrophin-3 (NT-3) in skeletal muscles was measured in rats with streptozotocin (STZ)- induced diabetes using Northern blot analysis. At 6 weeks after STZ induction of diabetes, the NT-3 mRNA level in the quadriceps and gastrocnemius muscles was decreased by 45 and 77%, respectively, compared with that in age-matched controls. Since NT-3 is considered to be essential for the maintenance of spinal proprioceptive afferent neurons, decreased NT-3 expression in target tissues would impair the integrity of afferent neurons and might be an earlier marker in the sensory neuronal damage observed in diabetes mellitus.
引用
收藏
页码：309 / 312
页数：4
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