Association of single nucleotide polymorphisms in the ANKRA2 and CD180 genes with bovine respiratory disease and presence of Mycobacterium avium subsp paratuberculosis

被引:11
作者
Casas, E. [1 ]
Garcia, M. D. [1 ]
Wells, J. E. [1 ]
Smith, T. P. L. [1 ]
机构
[1] ARS, USDA, US Meat Anim Res Ctr, Clay Ctr, NE USA
关键词
bovine chromosome 20; bovine respiratory disease; Johne's disease; single nucleotide polymorphism; QUANTITATIVE TRAIT LOCI; HOLSTEIN CATTLE; JOHNES-DISEASE; US HOLSTEINS; BEEF-CATTLE; INFECTION; IDENTIFICATION; MILK; SUSCEPTIBILITY; COMPLEX;
D O I
10.1111/j.1365-2052.2011.02189.x
中图分类号
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号
0905 ;
摘要
The objective was to determine whether single nucleotide polymorphisms (SNPs) in the ANKRA2 and CD180 genes are associated with incidence of bovine respiratory disease (BRD) and presence of Mycobacterium avium subsp. paratuberculosis (MAP) in cattle. Two independent populations were used. The first population (BRD-affected; N = 90) was composed of 31 half-sib progeny, from a Brahman x Angus sire, that were treated for BRD. Untreated offspring from the sire were selected to serve as controls. The second population (MAP-infected) of 330 animals of unknown parentage was evaluated for the presence of MAP in ileocecal lymph node and classified as positive or negative. Markers in both genes were assessed for association in these two populations. In the BRD-affected population, five SNPs in the ANKRA2 gene were significantly associated (P < 0.05), and two SNPs were highly associated (P < 0.01) with incidence of BRD. In addition, two SNPs in the CD180 gene were found to be associated with this trait. In the MAP-infected population, one SNP in the ANKRA2 gene was significantly associated (P < 0.05) with the presence or absence of MAP, and a SNP in the CD180 gene was highly associated (P < 0.01) with the trait. Haplotypes, using significant markers, showed a positive association with both incidence of BRD (P = 0.0001) and with the presence of MAP (P = 0.0032). Markers in the ANKRA2 and CD180 genes are associated with the ability of the animal to cope with pathogens.
引用
收藏
页码:571 / 577
页数:7
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