Epigenetics for the pediatric cardiologist

被引：7
|
作者：
Spearman, Andrew D. [1 ]
机构：
[1] Childrens Hosp Wisconsin, Med Coll Wisconsin, 9000 Wisconsin Ave, Milwaukee, WI 53201 USA
来源：
CONGENITAL HEART DISEASE | 2017年 / 12卷 / 06期
关键词：
congenital heart disease; DNA methylation; Epigenetics; histone modification; microRNA; precision medicine; HISTONE DEACETYLASE INHIBITORS; CONGENITAL HEART-DISEASE; AORTIC-VALVE DISEASE; CARDIOVASCULAR-DISEASE; DNA METHYLATION; CIRCULATING MICRORNA; HDAC INHIBITORS; EXPRESSION; HYPERTROPHY; MUTATIONS;
D O I：
10.1111/chd.12543
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A genetic basis of congenital heart disease (CHD) has been known for decades. In addition to the sequence of the genome, the contribution of epigenetics to pediatric cardiology is increasingly recognized. Multiple epigenetic mechanisms, including DNA methylation, histone modification, and RNA-based regulation, are known mediators of cardiovascular disease, including both development and progression of CHD and its sequelae. Basic understanding of the concepts of epigenetics will be essential to all pediatric cardiologists in order to understand mechanisms of pathophysiology, pharmacotherapeutic concepts, and to understand the role of epigenetics in precision medicine.
引用
收藏
页码：828 / 833
页数：6
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