Single extracellular vesicle analysis for early cancer detection

被引：49
|
作者：
Ferguson, Scott [1 ]
Yang, Katherine S. [1 ]
Weissleder, Ralph [1 ,2 ]
机构：
[1] Massachusetts Gen Hosp, Ctr Syst Biol, 185 Cambridge St, CPZN 5206, Boston, MA 02114 USA
[2] Harvard Med Sch, Dept Syst Biol, 200 Longwood Ave, Boston, MA 02115 USA
来源：
TRENDS IN MOLECULAR MEDICINE | 2022年 / 28卷 / 08期
基金：
美国国家卫生研究院;
关键词：
STOICHIOMETRIC ANALYSIS; MUTANT KRAS; EXOSOMES; SECRETION; IDENTIFICATION; MICROVESICLES; BIOGENESIS; DIAGNOSIS; DNA; MEDIATORS;
D O I：
10.1016/j.molmed.2022.05.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Extracellular vesicles (EVs) are actively shed into the circulation from both cancer and host cells. EVs are emerging as one of the diagnostic frontrunners for early cancer detection, disease monitoring, and treatment evaluation. The advantages of EVs rely on the fact that vesicles are being shed by dividing tumor cells, with indications that human and viral oncogenes, cellular metabolic rate, and tumor characteristics such as pH and hypoxia contribute to the high shed rates in cancer. In this review, we provide an overview of EVs and the rationale for using them for early cancer detection. We examine emerging technologies for single EV analysis (sEVA) and why these technologies will be necessary for early cancer detection.
引用
收藏
页码：681 / 692
页数：12
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