Iodine-promoted synthesis of pyrazoles from 1,3-dicarbonyl compounds and oxamic acid thiohydrazides

被引：24

作者：

Komendantova, Anna S. ^{[1
]}

Lyssenko, Konstantin A. ^{[2
,3
]}

Zavarzin, Igor, V ^{[1
]}

Volkova, Yulia A. ^{[1
]}

机构：

[1] Russian Acad Sci, ND Zelinsky Inst Organ Chem, 47 Leninsky Prosp, Moscow 119991, Russia

[2] GV Plekhanov Russian Univ Econ, 36 Stremyanny Per, Moscow 117997, Russia

[3] Moscow MV Lomonosov State Univ, Dept Chem, Moscow 119991, Russia

来源：

ORGANIC CHEMISTRY FRONTIERS | 2020年 / 7卷 / 13期

关键词：

REGIOSELECTIVE SYNTHESIS; MOLECULAR-IODINE; DERIVATIVES; CYCLOADDITION; HETEROCYCLES; CHEMISTRY; ESTERS;

D O I：

10.1039/d0qo00476f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel approach to the synthesis of 3,4-dicarbonyl-substituted pyrazoles from a wide range of 1,3-dicarbonyl compounds and oxamic acid thiohydrazides was developedviaiodine-promoted cascade imination/halogenation/cyclization/ring contraction reaction accompanied by sulfur elimination. This procedure provides a highly efficient and facile route to functionalized pyrazoles from readily available substrates under mild reaction conditions.

引用

页码：1640 / 1646

页数：7

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