Increased strontium uptake in trabecular bone of ovariectomized calcium-deficient rats treated with strontium ranelate or strontium chloride

被引：27

作者：

Pemmer, Bernhard ^{[2
]}

Hofstaetter, Jochen G. ^{[1
,3
]}

Meirer, Florian ^{[2
,4
]}

Smolek, Stephan ^{[2
]}

Wobrauschek, Peter ^{[2
]}

Simon, Rolf ^{[5
]}

Fuchs, Robyn K. ^{[6
]}

Allen, Matthew R. ^{[6
]}

Condon, Keith W. ^{[6
]}

Reinwald, Susan ^{[6
]}

Phipps, Roger J. ^{[7
]}

Burr, David B. ^{[6
,8
]}

Paschalis, Eleftherios P. ^{[1
]}

Klaushofer, Klaus ^{[1
]}

Streli, Christina ^{[2
]}

Roschger, Paul ^{[1
]}

机构：

[1] Hanusch Hosp, Ludwig Boltzmann Inst Osteol, WGKK & AUVA Trauma Ctr Meidling, Dept Med 1, A-1140 Vienna, Austria

[2] Vienna Univ Technol, Atominst, A-1020 Vienna, Austria

[3] Med Univ Vienna, Vienna Gen Hosp, Dept Orthopaed Surg, Vienna, Austria

[4] Fdn Bruno Kessler, MiNALab, CMM Irst, I-38123 Trento, Italy

[5] Karlsruhe Inst Technol, Inst Synchrotron Radiat, D-76344 Eggenstein Leopoldshafen, Germany

[6] Indiana Univ Sch Med, Dept Anat & Cell Biol, Indianapolis, IN USA

[7] Husson Univ, Sch Pharm, Bangor, ME 04401 USA

[8] IUPUI, Dept Biomed Engn, Indianapolis, IN USA

来源：

JOURNAL OF SYNCHROTRON RADIATION | 2011年 / 18卷

关键词：

strontium ranelate; strontium chloride; dietary calcium; ovariectomized rats; SR mu-XRF; qBEI; elemental mapping; principal component analysis; k-means clustering; X-RAY-FLUORESCENCE; DENSITY DISTRIBUTION; STABLE STRONTIUM; MINERAL CRYSTALS; OSTEOPOROSIS; QUALITY; CARTILAGE; BIOPSIES; RICKETS; XRF;

D O I：

10.1107/S090904951103038X

中图分类号：

TH7 [仪器、仪表];

学科分类号：

0804 ; 080401 ; 081102 ;

摘要：

Based on clinical trials showing the efficacy to reduce vertebral and non-vertebral fractures, strontium ranelate (SrR) has been approved in several countries for the treatment of postmenopausal osteoporosis. Hence, it is of special clinical interest to elucidate how the Sr uptake is influenced by dietary Ca deficiency as well as by the formula of Sr administration, SrR versus strontium chloride (SrCl(2)). Three-month-old ovariectomized rats were treated for 90 days with doses of 25 mg kg(-1) d(-1) and 150 mg kg(-1) d(-1) of SrR or SrCl(2) at low (0.1% Ca) or normal (1.19% Ca) Ca diet. Vertebral bone tissue was analysed by confocal synchrotron-radiation-induced micro X-ray fluorescence and by backscattered electron imaging. Principal component analysis and k-means clustering of the acquired elemental maps of Ca and Sr revealed that the newly formed bone exhibited the highest Sr fractions and that low Ca diet increased the Sr uptake by a factor of three to four. Furthermore, Sr uptake in bone of the SrCl(2)-treated animals was generally lower compared with SrR. The study clearly shows that inadequate nutritional calcium intake significantly increases uptake of Sr in serum as well as in trabecular bone matrix. This indicates that nutritional calcium intake as well as serum Ca levels are important regulators of any Sr treatment.

引用

页码：835 / 841

页数：7

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