Stem cell-based therapy for erectile dysfunction

被引:4
作者
Wu Jian-hong [1 ]
Xia Shu-jie [1 ]
机构
[1] Shanghai Jiao Tong Univ, Peoples Hosp 1, Dept Urol, Shanghai 200080, Peoples R China
关键词
stem cells; erectile dysfunction; cell based therapy; MARROW STROMAL CELLS; STRESS URINARY-INCONTINENCE; SMOOTH-MUSCLE-CELLS; IN-VITRO; RAT MODEL; PARACRINE MECHANISMS; NERVE REGENERATION; CORPUS CAVERNOSUM; PROGENITOR CELLS; SCHWANN-CELLS;
D O I
10.3760/cma.j.issn.0366-6999.2011.22.037
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective To review the effect of stem cells in erectile dysfunction as well as their application to the therapy of erectile dysfunction. Data sources The data used in the present article were mainly from Pub Med with relevant English articles published from 1974 to 2011. The search terms were "stem cells" and "erectile dysfunction". Study selection Articles regarding the role of stem cells in erectile dysfunction and their application to the therapy of erectile dysfunction were selected. Results Stem cells hold great promise for regenerative medicine because of their ability to self-renew and to differentiate into various cell types. Meanwhile, in preclinical experiments, therapeutic gene-modified stem cells have been approved to offer a novel strategy for cell therapy and gene therapy of erectile dysfunction. Conclusion The transplantation of stem cells has the potential to provide cell types capable of restoring normal function after injury or degradation inerectile dysfunction. However, a series of problems, such as the safety of stem cells transplantation, their application in cell therapy and gene therapy of erectile dysfunction need further investigation. Chin Med J 2011;124(22):3810-3815
引用
收藏
页码:3810 / 3815
页数:6
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