Urine D-ribose levels correlate with cognitive function in community-dwelling older adults

被引:6
|
作者
Zhu, Xinyi [1 ,2 ]
Wei, Yan [3 ]
He, Yingge [3 ]
He, Rongqiao [3 ]
Li, Juan [1 ,2 ]
机构
[1] Chinese Acad Sci, Ctr Aging Psychol, Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China
[2] Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
[3] Univ Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, 15 Datun Rd, Beijing 100101, Peoples R China
基金
中国国家自然科学基金;
关键词
D-ribose; MMSE; Verbal fluency; Cognitive impairment; Older adults; ALZHEIMERS-DISEASE; VERBAL FLUENCY; DEMENTIA; IMPAIRMENT; RISK;
D O I
10.1186/s12877-022-03288-w
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Background D-ribose is involved in the pathogenesis of Alzheimer's Disease. The study aimed to determine the association between D-ribose and cognitive function in a sample of community-dwelling older adults. Methods A cross-sectional study was conducted in Chaoyang District, Beijing in 2019-2020. Eligible participants were community-based older adults aged 60 years and above. D-ribose was analyzed from the morning urine. Cognitive function, subjective cognitive decline, and depressive symptoms were measured by a battery of neuropsychological tests. Linear regressions were performed to determine the relationship between the urine D-ribose levels and cognitive performance. Results A sample of 1725 participants (67.1% female) aged 60 to 85 years (69.40 +/- 5.87 years, mean +/- SD) was enrolled in the analysis. The urine D-ribose concentrations ranged from 1.53 to 208.89 mu mol/L (median 38.10 mu mol/L; interquartile range 22.52-64.96 mu mol/L). Higher levels of D-ribose were associated with worse performance on Mini-Mental State Examination and verbal fluency when age, gender, education, depressive symptoms, and cardiovascular risk factors were included as covariates. Conclusions The urine D-ribose was negatively correlated with cognitive function in community-dwelling older adults. The findings suggest that the dysmetabolism of D-ribose may play a role at the early stage of cognitive impairment.
引用
收藏
页数:9
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