Synthesis of novel 2,4,6-trisubstituted pyrimidine derivatives and their in vitro antimicrobial activity

被引：10
|
作者：
Ashok, D. [1 ]
Kumar, R. Suneel [2 ]
Gandhi, D. Mohan [1 ]
Jayashree, A. [3 ]
机构：
[1] Osmania Univ, Dept Chem, Hyderabad 500007, Andhra Pradesh, India
[2] Richmond Vivek Labs, Hyderabad 500076, Andhra Pradesh, India
[3] JNTUH, Ctr Chem Sci & Technol, IST, Hyderabad 500085, Andhra Pradesh, India
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2016年 / 86卷 / 06期
关键词：
chromanones; chalcones; pyrimidines; antimicrobial activity; CHALCONE DERIVATIVES; ISOPRENYL FLAVONOIDS;
D O I：
10.1134/S1070363216060268
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of novel pyrimidines (6a-6i) has been synthesized from corresponding chalcones and isonicotinimidamide.HCl in the presence of potassium carbonate involving Michael addition followed by cycloaddition. All newly synthesised chalcones and pyrimidines were screened for in vitro antimicrobial activity against various Gram positive, Gram negative bacterial and fungal strains. Most of compounds displayed high antimicrobial activity compared to standard drugs Penicillin, Streptomycin and Ampothericin-B.
引用
收藏
页码：1396 / 1404
页数：9
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