Total Synthesis of A Novel Tetracyclic Alkaloid, Cassiarin F from the Flowers of Cassia siamea

被引：19

作者：

Deguchi, Jun ^{[1
]}

Hirahara, Tomoe ^{[1
]}

Oshimi, Shiori ^{[1
]}

Hirasawa, Yusuke ^{[1
]}

Ekasari, Wiwied ^{[2
]}

Shirota, Osamu ^{[3
]}

Honda, Toshio ^{[1
]}

Morita, Hiroshi ^{[1
]}

机构：

[1] Hoshi Univ, Fac Pharmaceut Sci, Shinagawa Ku, Tokyo 1428501, Japan

[2] Airlangga Univ, Fac Pharm, Jalan Dharmawangsa Dalam 60286, Surabaya, Indonesia

[3] Tokushima Bunri Univ, Kagawa Campus, Fac Pharmaceut Sci, Sanuki City, Kagawa 7692193, Japan

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 16期

关键词：

VITRO ANTIPLASMODIAL ACTIVITY; HOUBEN-HOESCH; TRADITIONAL MEDICINE; INVOLVEMENT; GATTERMANN;

D O I：

10.1021/ol201674a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel alkaloid, cassiarin F (1), which showed potent antiplasmodial activity against Plasmodium falciparum In vitro, was isolated from the flowers of Cassia siamea, and Its structure was elucidated on the basis of 2D NMR analyses. A total synthesis of 1 was also achieved by employing the Suzuki coupling constructing biaryl unit, nucleophilic aromatic substitution, and Houben-Hoesch type ring construction as key steps.

引用

页码：4344 / 4347

页数：4

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