Solubility of ketoconazole in 1,4-dioxane + water mixtures at T= (293.2 to 313.2) K

被引：7

作者：

Barzegar-Jalali, Mohammad ^{[1
,7
]}

Agha, Elnaz Mazaher Haji ^{[2
]}

Adibkia, Khosro ^{[1
,7
]}

Martinez, Fleming ^{[3
]}

Kuentz, Martin ^{[4
]}

Jouyban, Abolghasem ^{[5
,6
,7
]}

机构：

[1] Tabriz Univ Med Sci, Res Ctr Pharmaceut Nanotechnol, Tabriz, Iran

[2] Tabriz Univ Med Sci, Biotechnol Res Ctr, Tabriz, Iran

[3] Univ Nacl Colombia, Fac Ciencias, Grp Invest Farmaceut Fisicoquim, Cra 30 45-03, Bogota, Colombia

[4] Univ Appl Sci & Arts Northwestern Switzerland, Inst Pharma Technol, Hofackerstr 30, CH-4132 Muttenz, Switzerland

[5] Tabriz Univ Med Sci, Pharmaceut Anal Res Ctr, Tabriz, Iran

[6] Univ Tehran Med Sci, Digest Dis Res Inst, Tehran, Iran

[7] Tabriz Univ Med Sci, Fac Pharm, Tabriz, Iran

来源：

JOURNAL OF MOLECULAR LIQUIDS | 2020年 / 306卷

关键词：

Solubility; 1,4-Dioxane; Ketoconazole; van't Hoff equation; Co-solvency models; Preferential solvation; BINARY COSOLVENT MIXTURES; PREFERENTIAL SOLVATION; SOLUTION THERMODYNAMICS; LIQUID-EQUILIBRIUM; WATER; EXPRESSION; DERIVATION; IBUPROFEN; SOLVENTS; SYSTEMS;

D O I：

10.1016/j.molliq.2020.112830

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The solubility of ketoconazole was measured in aqueous mixtures of 1,4-dioxane at T = (2932 to 313.2) K using the shake flask method. To mathematically represent the generated solubility data, combined nearly ideal binary solvent/Redlich-Kister (CNIBS/R-K), van't Hoff, Jouyban-Acree, Jouyban-Acree-van't Hoff, UNIQUAC, and NRTL models were applied. Differences of experimental and predicted values were expressed as the percentage of averaged relative deviation (% ARD). Apparent thermodynamic quantities of ketoconazole dissolution and mixing were reported at harmonic temperature. Moreover, the dissolution mechanism of ketoconazole was studied in 1,4-dioxane + water mixtures. Based on the inverse Kirkwood-Buff integrals, the preferential solvation parameters were calculated and it is observed that ketoconazole is preferentially solvated by water in water-rich and 1,4-dioxane-rich mixtures. (C) 2020 Elsevier B.V. All rights reserved.

引用

页数：10

共 43 条

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