Synthesis and cytotoxic activity of some novel benzocoumarin derivatives under solvent free conditions

被引：20

作者：

Abdel-Aziem, Anhar ^{[1
]}

Rashdan, Huda Refaat Mahmoud ^{[2
]}

Ahmed, Entesar Mohamed ^{[1
]}

Shabaan, Sara N. ^{[1
]}

机构：

[1] Al Azhar Univ, Dept Chem, Girls Branch, Fac Sci, Cairo, Egypt

[2] Natl Res Ctr, Pharmaceut & Drug Ind Res Div, Chem Nat & Microbial Prod Dept, Giza, Egypt

来源：

GREEN CHEMISTRY LETTERS AND REVIEWS | 2019年 / 12卷 / 01期

关键词：

Green chemistry; coumarins; hydrazonoyl halides; pyrazolo[3,4-d]pyridazines; sulphadrugs; cytotoxicity; PUTATIVE COGNITIVE ENHANCER; NATIONAL-CANCER-INSTITUTE; COUMARIN DERIVATIVES; DRUG DISCOVERY; ANTICOAGULATION; HETEROCYCLES; THERAPY;

D O I：

10.1080/17518253.2018.1556743

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In the present study, a rapid, less expensive, clean and environmental friendly route to synthesis new pyrazoles, pyrazolopyridazines and condensed pyrimidines was developed via grinding of 2-(3-(dimethylamino)acryloyl)-3H-benzo[f]chromen-3-one (1) with different reagents. All the new compounds were characterized and established using elemental analysis and spectral data. Eight compounds were selected for in vitro antiproliferative against different human cancer cell lines entitled melanoma, cancers of the lung, leukemia, breast, brain, colon, prostate, ovary and kidney by the USA NCI. [GRAPHICS] .

引用

页码：9 / 18

页数：10

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