Treatment for psychological dependence on morphine: Usefulness of inhibiting NMDA receptor and its associated protein kinase in the nucleus accumbens

被引：15
作者：
Narita, M [1 ]
Kato, H [1 ]
Miyoshi, K [1 ]
Aoki, T [1 ]
Yajima, Y [1 ]
Suzuki, T [1 ]
机构：
[1] Hoshi Univ, Sch Pharm & Pharmaceut Sci, Dept Toxicol, Shinagawa Ku, Tokyo 1428501, Japan
来源：
LIFE SCIENCES | 2005年 / 77卷 / 18期
关键词：
morphine; psychological dependence; nucleus accumbens; NR2B subunit-containing NMDA receptor; protein kinase C;
D O I：
10.1016/j.lfs.2005.04.015
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
A growing body of evidence indicates that the mesolimbic dopaminergic (DAergic) pathway projecting from the ventral tegmental area (VTA) to the nucleus accumbens (N.Acc.) play a critical role in the initiation of psychological dependence on morphine. As well as DAergic system, the involvement of non-DAergic neurotransmitter and neuromodulator systems in rewarding effects induced by morphine has been recently documented. We previously demonstrated that the morphine-induced rewarding effect was dramatically suppressed by co-treatment with NMDA receptor antagonists, such as dizocilpine (MK-801), ketamine and ifenprodil. Therefore, we propose here that inhibiting the N-methyl-D-aspartate (NMDA) receptor and its associated protein kinase in the N.Acc. is useful for the treatment for psychological dependence on morphine. The following review provides a summary of recent our findings regarding the role of NMDA receptor and its associated protein kinase in the development of psychological dependence on morphine. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码：2207 / 2220
页数：14
相关论文
共 29 条
  • [21] Modulation by dopamine D1-like receptors of synaptic transmission and NMDA receptors in rat nucleus accumbens is attenuated by the protein kinase C inhibitor Ro 32-0432
    Chergui, K
    Lacey, MG
    NEUROPHARMACOLOGY, 1999, 38 (02) : 223 - 231
  • [22] Downregulation of mGluR2/3 receptors during morphine withdrawal in rats impairs mGluR2/3-and NMDA receptor-dependent long-term depression in the nucleus accumbens
    Qian, Zhaoqiang
    Wu, Xiaojie
    Qiao, Yanning
    Shi, Meimei
    Liu, Zhiqiang
    Ren, Wei
    Han, Jing
    Zheng, Qiaohua
    NEUROSCIENCE LETTERS, 2019, 690 : 76 - 82
  • [23] Antisense oligonucleotide knockdown of mGlu5 receptor attenuates the antinociceptive tolerance and up-regulated expression of spinal protein kinase C associated with chronic morphine treatment
    Xu, Tao
    Chen, Moxi
    Zhou, Quanhong
    Xue, Ying
    Wang, Li
    De Arce, Vida J. Bil
    Zhang, Xiaoli
    Jiang, Wei
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2012, 683 (1-3) : 78 - 85
  • [24] Expression of activity-regulated cytoskeleton-associated protein (Arc/Arg3.1) in the nucleus accumbens is critical for the acquisition, expression and reinstatement of morphine-induced conditioned place preference
    Lv, Xiu-Fang
    Xu, Ya
    Han, Ji-Sheng
    Cui, Cai-Lian
    BEHAVIOURAL BRAIN RESEARCH, 2011, 223 (01) : 182 - 191
  • [25] Repeated quinpirole treatment increases cAMP-dependent protein kinase activity and CREB phosphorylation in nucleus accumbens and reverses quinpirole-induced sensorimotor gating deficits in rats
    Culm, KE
    Lugo-Escobar, N
    Hope, BT
    Hammer, RP
    NEUROPSYCHOPHARMACOLOGY, 2004, 29 (10) : 1823 - 1830
  • [26] Repeated Quinpirole Treatment Increases cAMP-Dependent Protein Kinase Activity and CREB Phosphorylation in Nucleus Accumbens and Reverses Quinpirole-Induced Sensorimotor Gating Deficits in Rats
    Kerry E Culm
    Natasha Lugo-Escobar
    Bruce T Hope
    Ronald P Hammer
    Neuropsychopharmacology, 2004, 29 : 1823 - 1830
  • [27] Enhanced morphine-induced behavioural effects and dopamine release in the nucleus accumbens in a transgenic mouse model of impaired glucocorticoid (type II) receptor function: influence of long-term treatment with the antidepressant moclobemide
    Sillaber, I
    Montkowski, A
    Landgraf, R
    Barden, N
    Holsboer, F
    Spanagel, R
    NEUROSCIENCE, 1998, 85 (02) : 415 - 426
  • [28] Inhibitory effect of spinal mGlu5 receptor antisense oligonucleotide on the up-regulated expression of spinal G protein associated with chronic morphine treatment
    Chen, Moxi
    Zhang, Xiaoli
    Xu, Hao
    Ma, Xiaqing
    Jiang, Wei
    Xu, Tao
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2014, 723 : 253 - 258
  • [29] Morphine-induced analgesic tolerance is associated with alteration of protein kinase C gamma and transient receptor potential vanilloid type 1 genes expression in rat lumbosacral cord and midbrain
    Ahmadi, Shamseddin
    Parvini, Neda
    PHYSIOLOGY AND PHARMACOLOGY, 2016, 20 (03): : 147 - 156
123