Decline in immunity to polio among young adults

被引：18

作者：

Grotto, I

Handsher, R

Gdalevich, M

Mimouni, D

Huerta, M

Green, MS

Mendelson, E

Shpilberg, O

机构：

[1] Israel Def Forces Med Corps, IL-02149 Military Post, Israel

[2] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel

[3] Minist Hlth, Cent Virol Lab, Tel Hashomer, Israel

[4] Minist Hlth, ICDC, Tel Hashomer, Israel

来源：

VACCINE | 2001年 / 19卷 / 30期

关键词：

poliovaccine; antibodies; immunity;

D O I：

10.1016/S0264-410X(01)00165-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A serologic survey was conducted on a population-based representative sample of 521 18-year-old soldiers recruited to the Israel Defence Forces in 1997. The prevalence of neutralizing antibodies and geometric mean titers (GMTs) against the three types of poliovirus (Mahoney, MEF and Saukett strains) were found to be 98.7%, (GMT - 169.95), 99.6%, (GMT - 297.14) and 96.4% (GMT - 59.48), respectively. These GMTs are markedly lower than those recorded 4 years after booster vaccination carried out during a 1988 polio outbreak, and suggest a decline in immunity against polio among young adults. These findings support the policy of routine revaccination of children and adolescents in countries at risk or imported polioviruses and or revaccination of adults traveling to areas to which polio is endemic. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：4162 / 4166

页数：5

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