RETRACTED: LncRNA INHBA-AS1 promotes cell growth, migration, and invasion of oral squamous cell carcinoma by sponging miR-143-3p (Retracted Article)

被引：1
|
作者：
Ma, W-Q [1 ]
Chen, J. [1 ]
Fang, W. [1 ]
Yang, X-Q [1 ]
Zhu, A. [1 ]
Zhang, D. [1 ]
Zhong, H-L [1 ]
Yang, B. [1 ]
Luo, Z. [1 ]
机构：
[1] Southern Med Univ, Stomatol Hosp, Guangzhou, Peoples R China
来源：
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES | 2020年 / 24卷 / 04期
关键词：
Long noncoding RNA; INHBA-AS1; Oral squamous cell carcinoma (OSCC); MiR-143-3p; LONG NONCODING RNA; COLORECTAL-CANCER; METASTASIS; PROGRESSION;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
OBJECTIVE: Recent studies have revealed that long noncoding RNAs (lncRNAs) play important roles in the progression of turnorigenesis. Oral squamous cell carcinoma is a disease widely widespread all over the world. The aim of this study was to identify how lncRNA INHBA-AS1 functions in the progression of OSCC. PATIENTS AND METHODS: LncRNA INHBA-AS1 expression in both OSCC cells and 48 paired tissue samples was detected by Real Time-quantitative Polymerase Chain Reaction (RT-qPCR). The function of INHBA-AS1 was identified by the transwell assay, wound healing assay, and proliferation assay in vitro. Meanwhile, the role of INHBA-AS1 was investigated through tumor formation assay in vivo. Furthermore, the underlying mechanism was explored by the luciferase assays and RNA immunoprecipitation assay (RIP). RESULTS: INHBA-AS1 was highly expressed in OSCC tissues when compared with adjacent tissue samples. The proliferation, invasion, and migration of OSCC cells were significantly inhibited after the knockdown of INHBA-AS1 in vitro. Meanwhile, the knockdown of INHBA-AS1 remarkably inhibited tumor growth and metastasis in vivo. Besides, miR-143-3p was down-regulated after the knockdown of INHBA-AS1 in vitro. The expression of miR143-3p was negatively correlated with the expression of INHBA-AS1 in OSCC tissues, In addition, miR-143-3p was directly targeted by INHBA-AS1. CONCLUSIONS: The knockdown of INHBA-AS1 repressed cell migration, invasion, and proliferation in OSCC by sponging miR-1433p. which might offer a new therapeutic intervention for OSCC patients.
引用
收藏
页码：1821 / 1828
页数：8
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