Drug Delivery by Controlling a Supramolecular Host-Guest Assembly with a Reversible Photoswitch

被引：63
作者：
Basilio, Nuno [1 ]
Pischel, Uwe [2 ,3 ]
机构：
[1] Univ Nova Lisboa, Fac Ciencias & Tecnol, Dept Quim, LAQV,Rede Quim & Tecnol REQUIMTE, P-2829516 Caparica, Portugal
[2] Univ Huelva, CIQSO Ctr Res Sustainable Chem, Campus El Carmen S-N, Huelva 21071, Spain
[3] Univ Huelva, Dept Chem, Campus El Carmen S-N, Huelva 21071, Spain
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2016年 / 22卷 / 43期
关键词：
cucurbiturils; drug delivery; flavylium; host-guest chemistry; photochemistry; MOLECULAR RECOGNITION; DIMERIC CAPSULES; PROTON-TRANSFER; PK(A) SHIFTS; RELEASE; COMPLEXES; LIGHT; SYSTEMS; CUCURBITURILS; STABILIZATION;
D O I：
10.1002/chem.201603331
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The reversibly switchable trans-chalcone/flavylium photochromic system was successfully coupled to the complexation equilibrium of a drug-cucurbit[7] uril host-guest assembly. Hence, the phototriggered release of memantine under illumination at 366 nm was observed. The process can be partially reverted through a thermally activated back reaction.
引用
收藏
页码：15208 / 15211
页数：4
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