PSGL-1 is dispensible for the development of active experimental autoimmune encephalomyelitis in SJL/J mice

被引：6

作者：

Bill, Ruben ^{[1
]}

Doering, Axinia ^{[1
]}

Deutsch, Urban ^{[1
]}

Engelhardt, Britta ^{[1
]}

机构：

[1] Univ Bern, Theodor Kocher Inst, CH-3012 Bern, Switzerland

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2011年 / 232卷 / 1-2期

关键词：

Gene targeted mice; Backcrossing; EAE; Modulatory genes; PSGL-1; SELECTIN GLYCOPROTEIN LIGAND-1; BLOOD-BRAIN-BARRIER; P-SELECTIN; MULTIPLE-SCLEROSIS; T-CELLS; C57BL/6; MICE; ANIMAL-MODEL; NATALIZUMAB;

D O I：

10.1016/j.jneuroim.2010.10.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The adhesion molecule P-selectin glycoprotein ligand (PSGL)-1 has been suggested to be involved in the immunopathogenesis of multiple sclerosis (MS). However, in C57BL/6 mice PSGL-1 was found to be dispensible for the development of MOG(aa35-55)-induced experimental autoimmune encephalomyelitis (EAE), an animal model for MS. To study, if involvement of PSGL-1 to EAE pathogenesis can be observed in another common mouse model, we backcrossed PSGL-1(-/-) mice for at least 12 generations into the SJL/J background and compared PLPaa139-151 induced EAE in PSGL-1(-/-) SJL/J mice versus wild-type SJL/J mice. Here, we demonstrate that PSGL-1(-/-) SJL/J mice exhibited EAE pathogenesis indistinguishable from wild-type SJL/J mice. Our present study underscores and emphasizes previous observations that PSGL-1 is dispensible for EAE pathogenesis. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：207 / 208

页数：2

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