Focal therapy in the management of localized prostate cancer

被引：16

作者：

Nguyen, Carvell T. ^{[1
]}

Jones, J. Stephen ^{[1
]}

机构：

[1] Cleveland Clin, Dept Reg Urol, Glickman Urol & Kidney Inst, Cleveland, OH 44195 USA

来源：

BJU INTERNATIONAL | 2011年 / 107卷 / 09期

关键词：

focal therapy; cryoablation; prostate cancer; INTENSITY-FOCUSED ULTRASOUND; QUALITY-OF-LIFE; CRYOSURGICAL ABLATION; 3RD-GENERATION CRYOSURGERY; RADICAL PROSTATECTOMY; TRANSRECTAL HIFU; FOLLOW-UP; EXPERIENCE; CRYOABLATION; OUTCOMES;

D O I：

10.1111/j.1464-410X.2010.09975.x

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVES To assess the rationale, efficacy, and morbidity of various methods of achieving focal prostatic ablation. To determine the current role of focal therapy in the management of localized prostate cancer. METHODS We performed a literature review of focal therapy in prostate cancer, with an emphasis on more established methods such as cryoablation and high-intensity focused ultrasound. RESULTS AND CONCLUSIONS Focal ablative methods allow targeted destruction of prostatic tissue while limiting the morbidity associated with whole-gland therapy. Local cancer control after focal therapy appears promising but does not approach that of established whole-gland therapies. Until we have the ability to identify patients reliably with truly focal disease and predict their natural history, focal therapy cannot be considered to be the definitive therapy for localized prostate cancer.

引用

页码：1362 / 1368

页数：7

共 64 条

[1] High-intensity-focused ultrasound in the treatment of primary prostate cancer: the first UK series [J].

Ahmed, H. U. ;

Zacharakis, E. ;

Dudderidge, T. ;

Armitage, J. N. ;

Scott, R. ;

Calleary, J. ;

Illing, R. ;

Kirkham, A. ;

Freeman, A. ;

Ogden, C. ;

Allen, C. ;

Emberton, M. .

BRITISH JOURNAL OF CANCER, 2009, 101 (01) :19-26

[2] Minimally-invasive technologies in uro-oncology: The role of cryotherapy, HIFU and photodynamic therapy in whole gland and focal therapy of localised prostate cancer [J].

Ahmed, Hashim Uddin ;

Moore, Caroline ;

Emberton, Mark .

SURGICAL ONCOLOGY-OXFORD, 2009, 18 (03) :219-232

[3] Mortality Results from a Randomized Prostate-Cancer Screening Trial [J].

Andriole, Gerald L. ;

Grubb, Robert L., III ;

Buys, Saundra S. ;

Chia, David ;

Church, Timothy R. ;

Fouad, Mona N. ;

Gelmann, Edward P. ;

Kvale, Paul A. ;

Reding, Douglas J. ;

Weissfeld, Joel L. ;

Yokochi, Lance A. ;

Crawford, E. David ;

O'Brien, Barbara ;

Clapp, Jonathan D. ;

Rathmell, Joshua M. ;

Riley, Thomas L. ;

Hayes, Richard B. ;

Kramer, Barnett S. ;

Izmirlian, Grant ;

Miller, Anthony B. ;

Pinsky, Paul F. ;

Prorok, Philip C. ;

Gohagan, John K. ;

Berg, Christine D. .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (13) :1310-1319

[4] Results of the 5 region prostate biopsy method: The repeat biopsy population [J].

Applewhite, JC ;

Matlaga, BR ;

McCullough, DL .

JOURNAL OF UROLOGY, 2002, 168 (02) :500-503

[5] Cryosurgical ablation of the prostate: 5-year follow-up of a prospective study [J].

Aus, G ;

Pilblad, E ;

Hugosson, J .

EUROPEAN UROLOGY, 2002, 42 (02) :133-138

[6] Targeted cryoablation of the prostate: 7-year outcomes in the primary treatment of prostate cancer [J].

Bahn, DK ;

Lee, F ;

Badalament, R ;

Kumar, A ;

Greski, J ;

Chernick, M .

UROLOGY, 2002, 60 (2A) :3-11

[7] Focal prostate cryoablation: Initial results show cancer control and potency preservation [J].

Bahn, Duke K. ;

Silverman, Paul ;

Lee, Fred ;

Badalament, Robert ;

Bahn, Eric D. ;

Rewcastle, John C. .

JOURNAL OF ENDOUROLOGY, 2006, 20 (09) :688-692

[8] Radical prostatectomy versus watchful waiting in early prostate cancer [J].

Bill-Axelson, A ;

Holmberg, L ;

Ruutu, M ;

Häggman, M ;

Andersson, SO ;

Bratell, S ;

Spångberg, A ;

Busch, C ;

Nordling, S ;

Garmo, H ;

Palmgren, J ;

Adami, HO ;

Norlén, BJ ;

Johansson, JE .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (19) :1977-1984

[9] High-intensity focused ultrasound for the treatment of localized prostate cancer: 5-year experience [J].

Blana, A ;

Walter, B ;

Rogenhofer, S ;

Wieland, WF .

UROLOGY, 2004, 63 (02) :297-300

[10] First analysis of the long-term results with transrectal HIFU in patients with localised prostate cancer [J].

Blana, Andreas ;

Murat, Francois J. ;

Walter, Bernhard ;

Thuroff, Stefan ;

Wieland, Wolf F. ;

Chaussy, Christian ;

Gelet, Albert .

EUROPEAN UROLOGY, 2008, 53 (06) :1194-1203

← 1 2 3 4 5 6 7 →