Reduced visual P300 amplitudes in individuals at ultra-high risk for psychosis and first-episode schizophrenia

被引：37

作者：

Lee, Su Young ^{[1
,2
]}

Namkoong, Kee ^{[1
,2
]}

Cho, Hye Hyun ^{[1
,2
]}

Song, Dong-Ho ^{[1
,2
]}

An, Suk Kyoon ^{[1
,2
]}

机构：

[1] Yonsei Univ, Coll Med, Dept Psychiat, Seoul 120752, South Korea

[2] Yonsei Univ, Coll Med, Inst Behav Sci Med, Seoul 120752, South Korea

来源：

NEUROSCIENCE LETTERS | 2010年 / 486卷 / 03期

关键词：

Ultra high risk for psychosis; First episode schizophrenia; P300; Event related potentials; Negative symptoms; Visuospatial oddball task; SPATIAL WORKING-MEMORY; BRAIN POTENTIALS; NEURAL ANOMALIES; AUDITORY P300; ENDOPHENOTYPE; METAANALYSIS; COMPONENT; WAVE; DEFINITION; PREDICTION;

D O I：

10.1016/j.neulet.2010.09.035

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The purpose of this study was to investigate whether individuals at ultra-high risk (UHR) for psychosis and patients experiencing first-episode schizophrenia had impairments in visual information processing as Indexed by the visual P300 event-related potential Sixteen UHR individuals 21 first-episode schizophrenia patients and 16 healthy controls were included Participants were asked to perform a visuospatial oddball task while undergoing an electroencephalogram The UHR and first-episode groups showed reduced P300 amplitudes in comparison to healthy controls P300 amplitudes were negatively correlated with severity of negative symptoms in both the UHR and first-episode groups These results suggest that the visual P300 may be a neurobiological vulnerability marker reflecting neurophysiological abnormalities associated with enduring negative symptoms in schizophrenia (C) 2010 Elsevier Ireland Ltd All rights reserved

引用

页码：156 / 160

页数：5

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