Nanostructured, Self-Assembled Spider Silk Materials for Biomedical Applications

被引：19

作者：

Humenik, Martin ^{[1
]}

Pawar, Kiran ^{[2
]}

Scheibel, Thomas ^{[3
,4
,5
,6
,7
]}

机构：

[1] Univ Bayreuth, Biomat, Fac Engn Sci, Bayreuth, Germany

[2] Univ British Columbia, Blusson Spinal Cord Ctr, Vancouver, BC, Canada

[3] Univ Bayreuth, Bayreuth Ctr Colloids & Interfaces BZKG, Bayreuth, Germany

[4] Univ Bayreuth, Res Ctr Biomacromol BIOmac, Bayreuth, Germany

[5] Univ Bayreuth, Bayreuth Ctr Mol Biosci BZMB, Bayreuth, Germany

[6] Univ Bayreuth, Bayreuth Ctr Mat Sci BayMAT, Bayreuth, Germany

[7] Univ Bayreuth, Bavarian Polymer Inst BPI, Bayreuth, Germany

来源：

BIOLOGICAL AND BIO-INSPIRED NANOMATERIALS: PROPERTIES AND ASSEMBLY MECHANISMS | 2019年 / 1174卷

关键词：

Biofabrication; Drug delivery; Fibers; Genetic engineering; Recombinant production; Self-assembly; Spider silk; Tissue engineering; N-TERMINAL DOMAIN; ATOMIC-FORCE MICROSCOPY; MAJOR AMPULLATE GLAND; SOLID-STATE NMR; DRAGLINE SILK; MECHANICAL-PROPERTIES; BLACK-WIDOW; RHEOLOGICAL CHARACTERIZATION; RECOMBINANT PRODUCTION; PROTEIN-COMPONENTS;

D O I：

10.1007/978-981-13-9791-2_6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The extraordinary mechanical properties of spider silk fibers result from the interplay of composition, structure and self-assembly of spider silk proteins (spidroins). Genetic approaches enabled the biotechnological production of recombinant spidroins which have been employed to unravel the self-assembly and spinning process. Various processing conditions allowed to explore non-natural morphologies including nanofibrils, particles, capsules, hydrogels, films or foams. Recombinant spider silk proteins and materials made thereof can be utilized for biomedical applications, such as drug delivery, tissue engineering or 3D-biomanufacturing.

引用

页码：187 / 221

页数：35

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