HIV-1 Tat: Its Dependence on Host Factors is Crystal Clear

被引：18
|
作者：
D'Orso, Ivan [1 ]
Frankel, Alan D. [1 ]
机构：
[1] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94158 USA
来源：
VIRUSES-BASEL | 2010年 / 2卷 / 10期
关键词：
HIV-1; Tat; transcription; P-TEFb; retroviruses; IMMUNODEFICIENCY-VIRUS TYPE-1; P-TEFB; TRANSCRIPTION ELONGATION; 7SK SNRNP; CYCLIN T1; IN-VITRO; RNA; PROTEIN; COMPLEX; ACTIVATION;
D O I：
10.3390/v2102226
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
HIV-1 transcription is regulated at the level of elongation by the viral Tat protein together with the cellular elongation factor P-TEFb, which is composed of cyclin T1 and Cdk9 subunits. The crystal structure of a Tat: P-TEFb complex (Tahirov, T.H.; Babayeva, N.D.; Varzavand, K.; Cooper, J.J.; Sedore, S.C.; and Price, D.H. Crystal structure of HIV-1 Tat complexed with human P-TEFb. Nature 2010, 465, 747-751.) reveals molecular details of Tat and its interactions that have eluded investigators for more than two decades and provides provocative insights into the mechanism of Tat activation.
引用
收藏
页码：2226 / 2234
页数：9
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