HIV-1 Tat: Its Dependence on Host Factors is Crystal Clear

被引：18

作者：

D'Orso, Ivan ^{[1
]}

Frankel, Alan D. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94158 USA

来源：

VIRUSES-BASEL | 2010年 / 2卷 / 10期

关键词：

HIV-1; Tat; transcription; P-TEFb; retroviruses; IMMUNODEFICIENCY-VIRUS TYPE-1; P-TEFB; TRANSCRIPTION ELONGATION; 7SK SNRNP; CYCLIN T1; IN-VITRO; RNA; PROTEIN; COMPLEX; ACTIVATION;

D O I：

10.3390/v2102226

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

HIV-1 transcription is regulated at the level of elongation by the viral Tat protein together with the cellular elongation factor P-TEFb, which is composed of cyclin T1 and Cdk9 subunits. The crystal structure of a Tat: P-TEFb complex (Tahirov, T.H.; Babayeva, N.D.; Varzavand, K.; Cooper, J.J.; Sedore, S.C.; and Price, D.H. Crystal structure of HIV-1 Tat complexed with human P-TEFb. Nature 2010, 465, 747-751.) reveals molecular details of Tat and its interactions that have eluded investigators for more than two decades and provides provocative insights into the mechanism of Tat activation.

引用

页码：2226 / 2234

页数：9

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