Retinal Vascular Layers Imaged by Fluorescein Angiography and Optical Coherence Tomography Angiography

被引:1236
作者
Spaide, Richard F. [1 ]
Klancnik, James M., Jr. [1 ]
Cooney, Michael J. [1 ]
机构
[1] Macula Consultants New York, Vitreous, Retina, New York, NY 10022 USA
关键词
RADIAL PERIPAPILLARY CAPILLARIES; ACUTE MIDDLE MACULOPATHY; MICROCIRCULATION; ISCHEMIA; NEOVASCULARIZATION; OPHTHALMOSCOPE; GLAUCOMA; ANATOMY; BLOOD;
D O I
10.1001/jamaophthalmol.2014.3616
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
IMPORTANCE The retinal vasculature is involved in many ocular diseases that cause visual loss. Although fluorescein angiography is the criterion standard for evaluating the retina vasculature, it has risks of adverse effects and known defects in imaging all the layers of the retinal vasculature. Optical coherence tomography (OCT) angiography can image vessels based on flow characteristics and may provide improved information. OBJECTIVE To investigate the ability of OCT angiography to image the vascular layers within the retina compared with conventional fluorescein angiography. DESIGN, SETTING, AND PARTICIPANTS In this study, performed from March 14, 2014, through June 24, 2014, a total of 5 consecutive, overlapping B-scan OCT angiography images composed of 216 A-scans were obtained at 216 discrete positions within a region of interest, typically a 2 x 2-mm area of the retina. The flow imaging was based on split-spectrum amplitude decorrelation angiography (SSADA), which can dissect layers of vessels in the retina. These distinct layers were compared with the fluorescein angiograms in 12 healthy eyes from patients at a private practice retina clinic to evaluate the ability to visualize the radial peripapillary capillary network. The proportion of the inner vs outer retinal vascular layers was estimated by 3 masked readers and compared with conventional fluorescein angiograms of the same eyes. MAIN OUTCOMES AND MEASURES Outcome measures were visualization of the radial peripapillary capillary network in the fluorescein and SSADA scans and the proportion of the inner retinal vascular plexus vs the outer retinal capillary plexus as seen in SSADA scans that would match the fluorescein angiogram. RESULTS In none of the 12 eyes could the radial peripapillary capillary network be visualized completely around the nerve head by fluorescein angiography, whereas the network was readily visualized in the SSADA scans. The fluorescein angiograms were matched, with a mean proportion of the inner vascular plexus being 95.3%(95% CI, 92.2%-97.8%) vs 4.7% (95% CI, 2.6%-5.7%) for the outer capillary plexus from the SSADA scans. CONCLUSIONS AND RELEVANCE Fluorescein angiography does not image the radial peripapillary or the deep capillary networks well. However, OCT angiography can image all layers of the retinal vasculature without dye injection. Therefore, OCT angiography, and the findings generated, have the potential to affect clinical evaluation of the retina in healthy patients and patients with disease.
引用
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页码:45 / 50
页数:6
相关论文
共 28 条
[1]   RADIAL PERIPAPILLARY CAPILLARIES OF RETINA .2. POSSIBLE ROLE IN BJERRUM SCOTOMA [J].
ALTERMAN, M ;
HENKIND, P .
BRITISH JOURNAL OF OPHTHALMOLOGY, 1968, 52 (01) :26-&
[2]  
[Anonymous], 1971, HISTOLOGY HUMAN EYE
[3]   Comparison of adaptive optics scanning light ophthalmoscopic fluorescein angiography and offset pinhole imaging [J].
Chui, Toco Y. P. ;
Dubow, Michael ;
Pinhas, Alexander ;
Shah, Nishit ;
Gan, Alexander ;
Weitz, Rishard ;
Sulai, Yusufu N. ;
Dubra, Alfredo ;
Rosen, Richard B. .
BIOMEDICAL OPTICS EXPRESS, 2014, 5 (04) :1173-1189
[4]   The use of forward scatter to improve retinal vascular imaging with an adaptive optics scanning laser ophthalmoscope [J].
Chui, Toco Y. P. ;
VanNasdale, Dean A. ;
Burns, Stephen A. .
BIOMEDICAL OPTICS EXPRESS, 2012, 3 (10) :2537-2549
[5]   In vivo imaging of the microcirculation of the volar forearm using correlation mapping optical coherence tomography (cmOCT) [J].
Enfield, Joey ;
Jonathan, Enock ;
Leahy, Martin .
BIOMEDICAL OPTICS EXPRESS, 2011, 2 (05) :1184-1193
[6]   RETINAL CIRCULATION TIME WITH THE AID OF FUNDUS CINEPHOTOGRAPHY [J].
FLOCKS, M ;
MILLER, J ;
CHAO, P .
AMERICAN JOURNAL OF OPHTHALMOLOGY, 1959, 48 (01) :3-6
[7]   Retinal ischemia and angle neovascularization in proliferative diabetic retinopathy [J].
Hamanaka, T ;
Akabane, N ;
Yajima, T ;
Takahashi, T ;
Tanabe, A .
AMERICAN JOURNAL OF OPHTHALMOLOGY, 2001, 132 (05) :648-658
[9]  
HENKIND PAUL, 1967, INVEST OPHTHALMOL, V6, P103
[10]   Quantitative Optical Coherence Tomography Angiography of Choroidal Neovascularization in Age-Related Macular Degeneration [J].
Jia, Yali ;
Bailey, Steven T. ;
Wilson, David J. ;
Tan, Ou ;
Klein, Michael L. ;
Flaxel, Christina J. ;
Potsaid, Benjamin ;
Liu, Jonathan J. ;
Lu, Chen D. ;
Kraus, Martin F. ;
Fujimoto, James G. ;
Huang, David .
OPHTHALMOLOGY, 2014, 121 (07) :1435-1444