Smart Polymeric Nanoparticles for Cancer Gene Delivery

被引：126
作者：
Lin, Guimei [1 ]
Zhang, Hong [1 ,2 ,3 ]
Huang, Leaf
机构：
[1] Shandong Univ, Sch Pharmaceut Sci, Jinan 250012, Shandong, Peoples R China
[2] Univ N Carolina, Eshelman Sch Pharm, Div Mol Pharmaceut, Chapel Hill, NC 27599 USA
[3] Yuxi Municipal Hosp Tradit Chinese Med, Yuxi 653100, Peoples R China
来源：
MOLECULAR PHARMACEUTICS | 2015年 / 12卷 / 02期
基金：
中国国家自然科学基金;
关键词：
gene delivery; cancer therapy; nanoparticle; CHITOSAN-GRAFT-POLYETHYLENIMINE; MESOPOROUS SILICA NANOPARTICLES; IRON-OXIDE NANOPARTICLES; TARGETED CO-DELIVERY; DRUG-DELIVERY; IN-VIVO; SIRNA DELIVERY; BREAST-CANCER; MULTIFUNCTIONAL NANOPARTICLES; SURFACE MODIFICATION;
D O I：
10.1021/mp500656v
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The massive amount of human genetic information already available has accelerated the identification of target genes, making gene and nucleic acid therapy the next generation of medicine. Nanoparticle (NP)-based anticancer gene therapy treatment has received significant interest in this evolving field. Recent advances in vector technology have improved gene transfection efficiencies of nonviral vectors to a level similar to viruses. This review serves as an introduction to surface modifications of NPs based on polymeric structural improvements and target moieties. A discussion regarding the future perspective of multifunctional NPs in cancer therapy is also included.
引用
收藏
页码：314 / 321
页数：8
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