Smart Polymeric Nanoparticles for Cancer Gene Delivery

被引：126

作者：

Lin, Guimei ^{[1
]}

Zhang, Hong ^{[1
,2
,3
]}

Huang, Leaf

机构：

[1] Shandong Univ, Sch Pharmaceut Sci, Jinan 250012, Shandong, Peoples R China

[2] Univ N Carolina, Eshelman Sch Pharm, Div Mol Pharmaceut, Chapel Hill, NC 27599 USA

[3] Yuxi Municipal Hosp Tradit Chinese Med, Yuxi 653100, Peoples R China

来源：

MOLECULAR PHARMACEUTICS | 2015年 / 12卷 / 02期

基金：

中国国家自然科学基金;

关键词：

gene delivery; cancer therapy; nanoparticle; CHITOSAN-GRAFT-POLYETHYLENIMINE; MESOPOROUS SILICA NANOPARTICLES; IRON-OXIDE NANOPARTICLES; TARGETED CO-DELIVERY; DRUG-DELIVERY; IN-VIVO; SIRNA DELIVERY; BREAST-CANCER; MULTIFUNCTIONAL NANOPARTICLES; SURFACE MODIFICATION;

D O I：

10.1021/mp500656v

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The massive amount of human genetic information already available has accelerated the identification of target genes, making gene and nucleic acid therapy the next generation of medicine. Nanoparticle (NP)-based anticancer gene therapy treatment has received significant interest in this evolving field. Recent advances in vector technology have improved gene transfection efficiencies of nonviral vectors to a level similar to viruses. This review serves as an introduction to surface modifications of NPs based on polymeric structural improvements and target moieties. A discussion regarding the future perspective of multifunctional NPs in cancer therapy is also included.

引用

页码：314 / 321

页数：8

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