Jenamidines A to C:: Unusual alkaloids from Streptomyces sp with specific antiproliferative properties obtained by chemical screening

被引：26

作者：

Hu, JF

Wunderlich, D

Thiericke, R

Dahse, HM

Grabley, S

Feng, XZ

Sattler, I

机构：

[1] Hans Knoll Inst Nat Prod Res, D-07745 Jena, Germany

[2] Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China

[3] Peking Union Med Coll, Beijing 100050, Peoples R China

来源：

JOURNAL OF ANTIBIOTICS | 2003年 / 56卷 / 09期

关键词：

D O I：

10.7164/antibiotics.56.747

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Three new naturally occurring bicyclic alkaloids, jenamidines A (1), B (2) and C (3), were discovered and isolated from the culture broth of Streptomyces sp. (strain HKI0297) via the chemical screening approach. Fermentation, isolation, structure and biological activities of these three new secondary metabolites are reported. The jenamidines have an unusual octahydro-pyrido[1,2-a]pyrimidine skeleton. Jenamidine A (1) shows antiproliferative effects against the chronic myeloid leukaemic cell line K-562. In addition, the new tricyclic sesquiterpenoid, africantriol (4) was isolated from the same strain.

引用

页码：747 / 754

页数：8

共 12 条

[1] NEW TRANS-FUSED AFRICANOLS FROM LEPTOGRAPHIUM-LUNDBERGII [J].

ABRAHAM, WR ;

ERNST, L ;

WITTE, L ;

HANSSEN, HP ;

SPRECHER, E .

TETRAHEDRON, 1986, 42 (16) :4475-4480

[2] New cineromycins and musacins obtained by metabolite pattern analysis of Streptomyces griseoviridis (FH-S 1832) .1. Taxonomy, fermentation, isolation and biological activity [J].

Burkhardt, K ;

Fiedler, HP ;

Grabley, S ;

Thiericke, R ;

Zeeck, A .

JOURNAL OF ANTIBIOTICS, 1996, 49 (05) :432-437

[3] 4,5-SECO-AFRICAN-4,5-DIONE FROM LIPPIA-INTEGRIFOLIA [J].

CATALAN, CAN ;

DEFENIK, IJS ;

DEARRIAZU, PJ ;

KOKKE, WCMC .

PHYTOCHEMISTRY, 1992, 31 (11) :4025-4026

[4]

Dahse HM, 2001, PHARMAZIE, V56, P489

[5] Sesquiterpenes from Lippia integrifolia essential oil [J].

Fricke, C ;

Hardt, IH ;

König, WA ;

Joulain, D ;

Zygadlo, JA ;

Guzmàn, CA .

JOURNAL OF NATURAL PRODUCTS, 1999, 62 (05) :694-696

[6]

Gohrt A, 1996, LIEBIGS ANN, P627

[7]

Grabley S, 2000, SPR DESKT EDIT CHEM, P124

[8] New 1-O-acyl α-L-rhamnopyranosides and rhamnosylated lactones from Streptomyces sp., inhibitors of 3α-hydroxysteroid-dehydrogenase (3α-HSD) [J].

Hu, JF ;

Wunderlich, D ;

Sattler, I ;

Härtl, A ;

Papastavrou, I ;

Grond, S ;

Grabley, S ;

Feng, XZ ;

Thiericke, R .

JOURNAL OF ANTIBIOTICS, 2000, 53 (09) :944-953

[9]

Hu JF, 2000, EUR J ORG CHEM, V2000, P3353

[10]

HU JF, 2003, IN PRESS NAT PROD LE

← 1 2 →