The Interferon Inducible Gene: Viperin

被引：128

作者：

Fitzgerald, Katherine A. ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Med, Div Infect Dis & Immunol, Worcester, MA 01605 USA

来源：

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH | 2011年 / 31卷 / 01期

关键词：

AMPHIPATHIC ALPHA-HELIX; LIPID RAFT MICRODOMAINS; HEPATITIS-C; ANTIVIRAL PROTEIN; RNA REPLICATION; VIRUS; LOCALIZATION; RECOGNITION; CYTOMEGALOVIRUS; EXPRESSION;

D O I：

10.1089/jir.2010.0127

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The type I interferons (IFNs), IFN-alpha and -beta, are key effector molecules of the immune response to viruses. The anti-viral action of IFNs on virus-infected cells and surrounding tissues is mediated by expression of hundreds of IFN-stimulated genes. Viperin (virus inhibitory protein, endoplasmic reticulum-associated, IFN-inducible) is an Interferon stimulated gene (ISG), which is induced by type I, II, and III IFNs or after infection with a broad range of DNA and RNA viruses. Recent evidence indicates that Viperin disrupts lipid rafts to block influenza virus budding and release and interferes with replication of hepatitis C virus by binding to lipid droplets, small organelles involved in lipid homeostasis that are essential for hepatitis C virus replication. Viperin is also induced by nonviral microbial products such as lipopolysaccharide (LPS) and by a wide range of bacteria, suggesting a broader role in innate antimicrobial defenses.

引用

页码：131 / 135

页数：5

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