Seroprevalance of Chlamydophila pneumoniae in Patients With Alzheimer's Disease and Vascular Dementia

被引：0

作者：

Ecemis, Talat ^{[1
]}

Mavioglu, Hatice ^{[2
]}

Ozkutuk, Nuri ^{[1
]}

Akcali, Sinem ^{[1
]}

Karacam, Melek ^{[2
]}

Sanlidag, Tamer ^{[1
]}

机构：

[1] Celal Bayar Univ, Tip Fak, Tibbi Mikrobiyoloji Anabilim Dali, Manisa, Turkey

[2] Celal Bayar Univ, Tip Fak, Noroloji Anabilim Dali, Manisa, Turkey

来源：

JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH | 2010年 / 27卷 / 04期

关键词：

C; pneumoniae; seroprevalance; Alzheimer's disease; vascular dementia; DETECT CHLAMYDIA-PNEUMONIAE; CORONARY-HEART-DISEASE; ISCHEMIC-STROKE; ASSOCIATION; ANTIBODIES; FAILURE; PREVALENCE; INFECTION; BRAIN; RISK;

D O I：

暂无

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In recent years, it was been argued that Chlamydophila pneumoniae, which is an intracellular pathogen capable of causing chronic infection, might be effective in some forms of dementia, an argument confirmed or rejected by some studies. The objective of this study was to determine if there was an association between C. pneumoniae infection and Alzheimer's disease and vascular dementia. We tested 54 patients with Alzheimer and 29 patients with vascular dementia and 50 controls for C. pneumoniae IgG and IgA antibodies and analyzed the results statistically. C. pneumoniae IgG antibodies were found in 25 patients (49.2%) with Alzheimer's disease, 15 patients (51.8%) with vascular dementia and 22 controls (44%) whereas 6 patients (11.1%), 2 patients (6.9%) and 3 controls (6%), respectively, tested positive for IgA. It was found no serological evidence for a significant association between C. pneumoniae and Alzheimer's disease as well as vascular dementia.

引用

页码：400 / 406

页数：7

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