Three New Sesquiterpene Glycosides from the Rhizomes of Trillium tschonoskii

被引：1

作者：

Yang, Jie ^{[1
,2
]}

Yang, Yin-Jun ^{[2
,3
]}

Sun, Xin-Guang ^{[2
]}

Zhang, Jie ^{[2
]}

Zhao, Yang ^{[2
]}

Wang, Bei ^{[1
,2
]}

Ding, Qian-Zhi ^{[2
]}

Guo, Bao-Lin ^{[3
]}

Ma, Bai-Ping ^{[1
,2
]}

机构：

[1] Guangdong Pharmaceut Univ, Sch Tradit Chinese Med, Guangzhou 510006, Guangdong, Peoples R China

[2] Beijing Inst Radiat Med, 27 Taiping Rd, Beijing 100850, Peoples R China

[3] Chinese Acad Med Sci, Inst Med Plant Dev, Beijing 100193, Peoples R China

来源：

MOLECULES | 2017年 / 22卷 / 08期

关键词：

Trillium tschonoskii; sesquiterpene glycosides; separation; UNDERGROUND PARTS; STEROIDAL SAPONINS; ROOTS; ERECTUM;

D O I：

10.3390/molecules22081283

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three new sesquiterpene glycosides, possessing a rare aglycone with a sulfonyl between C-1 and C-15 positions, named 3-(3'E-7'R,8'-dihydroxy-4',8'-dimethyl-3'-nonenyl)-2,5-dihydro-1,1-dioxo-thiophen 7'-O-beta-D-glucopyranosyl-(1 -> 4)-O-beta-D-glucopyranosyl-(1 -> 4)-O-beta-D-glucopyranoside (1), 3-(3'E-7'R,8'-dihydroxy-4'8'-dimethyl-3'-nonenyl)-2,5-dihydro-1,1-dioxothiophen 7'-O-beta-D-glucopyranosyl-(1 -> 4)-O-beta-D-glucopyranoside (2), and 3-(3'E-7'R,8'-dihydroxy-4 0,8-dimethyl-3'-nonenyl)-2,5-dihydro-1,1-dioxo-thiophen 7'-O-beta-D-glucopyranosyl-6'-O-acetyl(1 -> 4)-O-beta-D-glucopyranosyl-(1 -> 4)-O-beta-D-glucopyranoside (3), respectively, were isolated from the rhizomes of Trillium tschonoskii. Their structures were established on the basis of spectroscopic data, including HR-ESI-MS, IR, 1D and 2D NMR. The cytotoxic properties of the three compounds were investigated using human hepatic L02 cells.

引用

页数：7

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