Type-specific herpes simplex virus-1 and herpes simplex virus-2 seroprevalence in Romania: comparison of prevalence and risk factors in women and men

被引:17
作者
Arama, V. [2 ]
Cercel, A. Streinu [2 ]
Vladareanu, R. [3 ]
Mihai, C. [4 ]
Mihailescu, R. [2 ]
Rankin, J. [5 ]
Goschin, S. [2 ]
Filipescu, A. [3 ]
Rafila, A. [4 ]
Arama, S. [4 ]
Hristea, A. [2 ]
Malkin, J. E. [6 ]
Pimenta, J. M. [7 ]
Smith, J. S. [1 ]
机构
[1] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC 27599 USA
[2] Prof Dr Matei Bals Natl Infect Dis Inst, Bucharest, Romania
[3] Elias Univ Emergency Hosp, Dept Obstet & Gynecol, Bucharest, Romania
[4] Carol Davila Univ Med & Pharm, Bucharest, Romania
[5] Populat Council, New York, NY 10021 USA
[6] Inst Pasteur, Ctr Med, Paris, France
[7] GlaxoSmithKline Inc, Worldwide Epidemiol, Greenford, Middx, England
关键词
Herpes simplex virus types 1 and 2; Seropositivity; Risk factors; Romania; GENITAL HERPES; UNITED-STATES; INFECTION; HSV-1;
D O I
10.1016/j.ijid.2009.07.026
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Objective: To determine herpes simplex virus (HSV)-2 and HSV-1 seroprevalence in women and men in Romania. Methods: A cross-sectional seroprevalence survey was conducted between 2004 and 2005 on a total of 1058 women and men representative of the population of Bucharest. All participants were aged 15-44 years and completed a structured questionnaire. A blood sample was collected to detect IgG anti-HSV-1 and HSV-2 serum antibodies using the HerpeSelect ELISA (Focus Diagnostics). Results: A total of 761 women (median age 29 years) and 297 men (median age 29 years) were included. Overall, HSV-2 seroprevalence (15.2%) increased with age. Among women, HSV-2 seroprevalence increased from 11.0% in 15-19-year-olds to 38.3% in 40-44-year-olds. Among men, seroprevalence increased from 4.0% in 20-24-year-olds to 27.1% in 40-44-year-olds. HSV-2 seroprevalence was significantly higher among women than men (17.0% vs. 10.8%). HSV-1 seropositivity was high (87.2%) in all age groups, with no clear trend by age or by sex. In addition to older age and female sex, risk factors for HSV-2 included greater number of lifetime sexual partners, lower educational attainment, and history of genital vesicles. Lower educational level and rural residence were associated with a higher risk of HSV-1 seropositivity. Conclusions: In Romania, HSV-2 seroprevalence was higher in women than men, and was within European limits and lower than that in Africa and the USA. In contrast, HSV-1 seroprevalence was generally higher than that previously recorded in similarly aged populations in Western Europe. (C) 2010 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:E25 / E31
页数:7
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