Transformation of primary myelofibrosis with 20q-in Philadelphia-positive acute lymphoblastic leukemia: Case report and review of literature

被引：8

作者：

Jurisic, Vladimir ^{[1
]}

Colovic, Natasa ^{[2
,3
]}

Terzic, Tatjana ^{[2
,3
]}

Djordjevic, Vesna ^{[2
]}

Colovic, Milica ^{[3
]}

机构：

[1] Univ Kragujevac, Fac Med, Kragujevac 34000, Serbia

[2] Clin Ctr Serbia, Inst Hematol, Belgrade, Serbia

[3] Univ Belgrade, Fac Med, Belgrade, Serbia

来源：

PATHOLOGY RESEARCH AND PRACTICE | 2012年 / 208卷 / 07期

关键词：

Myelofibrosis; 20q-; Philadelphia chromosome; ALL; Cytogenetics; Mutation; Transformation; Immunophenotype; MYELODYSPLASTIC SYNDROMES; MYELOID METAPLASIA; DELETION; DIAGNOSIS; DEL(20Q); PATIENT;

D O I：

10.1016/j.prp.2012.04.007

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

A 56-year-old male with chronic idiopathic myelofibrosis and cytogenetic finding of 20q- after a period of 10 months developed acute Philadelphia-positive lymphoblastic leukemia. Immunophenotyping of peripheral blood by flow cytometry showed HLA-DR, CD34, CD19, CD22, CD10, CD33, and CD11b positivity. Cytogenetic analysis revealed the presence of 20q- and Philadelphia chromosome t(9;22)(q34:q11) at the time of disease transformation to ALL. The JAK2V617F mutation was not found. This is a very rare case of simultaneous presence of two cytogenetics abnormalities and evolution of primary idiopathic myelofibrosis to Philadelphia-positive acute lymphoblastic leukemia. (C) 2012 Elsevier GmbH. All rights reserved.

引用

页码：420 / 423

页数：4

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